Receive TWO (2) FREE Bottles of MegaSporeBiotic ($110 value) with your purchase of the BiomeFx Test Kit!

Recent evidence suggests that the gut microbiome is likely the master control center of overall human health. BiomeFx™ is the superior stool test on the market because of its coring method stool sampling, highly accurate whole-genome analysis and practical, user-friendly reporting.

Your purchase includes the following:

A New Way to Test — Whole Genome

Recent evidence suggests that the gut microbiome is likely the master control center of overall human health.
Stool testing has been a staple in the arsenal of functional medicine practitioners since the beginning. Unfortunately, there are many problems which lead to extremely limited functional use. As we’ve discussed on many microbiome and GI-related webinars over the years – we have hesitated to recommend and/or use stool testing personally because of these issues.

Problems with Stool Testing

  • Most tests use 16s (or even earlier) technology, which has a host of drawbacks (see below)
  • Many reports use arbitrary ranges that haven’t been well-established using healthy populations
  • Most don’t afford much practical, useful information
  • People often end up confused and unsure how to proceed based on their results
  • Look at individual microbes, not the larger context of microbiome community or function

Drawbacks of 16s Sequencing

  • Inaccurate on the species level – unable to effectively identify specific species of bacteria
  • Cheap to run – but the tests often have high price tags
  • High rate of false positives

Our friends over at Microbiome Labs have been sent hundreds (probably thousands) of stool test reports over the years, from people looking for guidance on what to do with their results – only to disappoint them by sharing the above information about inaccuracies, arbitrary reference ranges, and a general lack of actionable data provided.

For this reason, they never endorsed or recommended a specific stool test to use in clinical practice.

But the calls for help and nudges to create something better grew louder, so they started investigating any other potential technologies or testing methods that might yield more useful results.

Whole Genome Sequencing is a much more effective testing technology than 16s but has always been rather cost-prohibitive/too expensive to use in most cases. Tests using whole-genome sequencing had usually cost upwards of $1000+, well out of the range for most individuals. When exploring options for an affordable way to create a test using whole-genome sequencing, they found CosmosID and knew they’d found their partner in this endeavor.

Why Cosmos ID?

  • Their whole genome sequencing has 98-99% accuracy in species identification
  • Ability to create a customized test that would be within a reasonable price range
  • Industry leaders in microbiome testing and data analysis
  • Founder, Rita Colwell, is the most qualified scientist in the world when it comes to sequencing and building & creating interpretive data

For any baseball aficionados out there, Rita Colwell is the Babe Ruth of microbiome sequencing and data interpretation. Here’s a brief synopsis of her career and credentials:

  • Professor at the University of Maryland & Johns Hopkins University
  • The 11th Director of the National Science Foundation (1998-2004)
  • The President of the American Society of Microbiology (1984-1985)
  • Member of the National Academy of Science, the Royal Swedish Academy of Sciences, the Royal Society of Canada, and The American Academy of Arts & Sciences
  • Has Authored or co-authored more than 800 scientific reports and publications along with 19 books
  • Holds 64 honorary degrees
  • Awards include: National Medal of Science (2006), Stockholm Water Prize (2010), The Order of the Rising Sun-Gold and Silver Star (2005), National Women’s Hall of Fame (2005), Vannevar Bush Award (2017)

Once a partner was established, the work began to determine the goals of the test and subsequent reports created from the results. Using whole genome sequencing, the problem of accuracy was solved. Due to the incredible amount of data they now had access to with CosmosID, it would also be possible to map the entire community in context and compare the results with good data of healthy populations. This would provide the ability to understand interactions, correlate the results to disease prevalence, and give customized, actionable steps people can take – relevant to their own microbiome ecology.

There are still limits to even the best stool testing – and even this test is not a diagnostic tool… but it can be helpful in determining a successful course of action for each individual.

Why BiomeFx

The customized report is divided into several main sections which look at/provide the following:

  • A Microbiome Index Score which looks at trends in your microbiome compared to a database of healthy individuals with no chronic disease.
  • Alpha Diversity looks at the overall diversity of your microbiome (# of species found vs. healthy average)
  • Beta Diversity looks at the composition of your bacteria based on your specific geographical location (healthy individuals in US look different than those in Africa, Asia, Europe, etc…)
  • Resistome – The measures ecological forces within the microbiome that create competition within the population. A high number here indicates low vulnerability in microbial population.
  • Pathogen Control Index looks at the abundance of pathogenic organisms in relation to the overall microbiome. This score would indicate your microbiome’s ability to control pathogens.
  • A specific look at over 20 different common pathogens
  • Big picture/Phylum level ratios – We know certain proportions are important when it comes to health outcomes. Ex- One ratio is known to contribute to metabolic dysfunctions when dysbiotic/out of balance.
  • 30+ Function Groups – Another unique feature explores specific groups of microbes which perform specific functions. This may help determine what your microbiome is doing well (or not-so-well) and help create an optimal regimen for yourself when it comes to actionable steps to improve function.
  • Analyze Keystone Strain Levels – Strains that are known to be very important for maintaining health & structure of the microbiome.

This and much more is included with the 20+ page customized results report.

Also, in addition to the PDF/printable report – if ordered through Rebel Health Tribe, your report will be accompanied with an additional customized video breakdown of your results from a trained professional who has been educated in interpretation of the BiomeFx reports.

In summary, here are the unique features of the BiomeFx Test & Report:

  • Whole Genome Sequencing with 98+% accuracy
  • Partnered with CosmosID, the industry leader in microbiome testing & analysis
  • Compare results to a diverse database of healthy individuals
  • Resistome and Pathobiome Assessments to determine the resilience of your microbiome
  • Over 30+ Function Groups to explore how efficiently and effectively your microbiome is performing its functions
  • Keystone Strain Levels – known to be important for maintaining health & structure of microbiome
  • Tests for over 20 different common pathogens and overall pathogenic load
  • Personalized diet, nutrition, and supplementation recommendations based on your individual results
  • 40+ Page Report with all this information and much more!

Plus, a customized professional video review of your results to make sure everything is crystal clear regarding the report and actionable steps you can take moving forward to improve the health, diversity, and function of your microbiome!

BiomeFX Technology

A New Way to Test — Whole Genome

Recent evidence suggests that the gut microbiome is likely the master control center of overall human health. In recent years, stool testing has become a popular method to evaluate the status of an individual’s gut microbiome (1). Peering into these microbial ecosystems can offer insight into disease susceptibility and potential root causes of illness. In fact, many diseases have a unique ‘microbial signature’ or enterotype, which means that specific bacterial patterns can be consistently linked to a particular disease. Fecal sampling can help clinicians and patients understand how their gut bacteria may be contributing to their ailments and how they can improve their gut microbiomes (2). However, common methods of stool analysis are often inaccurate, and many reports offered to consumers are confusing, ambiguous, and not actually based upon scientific evidence.

The most commonly used analysis techniques include 16S rRNA gene sequencing (16S) and quantified polymerase chain reactions (QPCR). Essentially, 16S rRNA is a region of DNA present in all bacteria and archaea, but not necessarily in other microbes, such as fungi or viruses. The 16S gene contains 9 hypervariable regions that can be thought of as a barcode, encoding many bacterial taxa (2). This area of DNA is then amplified using QPCR techniques to predict the full DNA sequence. However, due to its imprecise predictive nature, QPCR offers vague and often inaccurate results.

Similarly, researchers have found that 16S genome sequencing has less than 50% accuracy in identifying microbial species (3). It offers insight into phyla and genera, but due to its use of low-resolution images, it does not offer enough precise detail about bacteria at the species level, which can be very important! For example, the bacteria Escheria coli has many strains. Some of these are pathogenic, while others strains of E. coli are protective. Furthermore, 16S is unable to distinguish between living or dead cells, or offer insight into their metabolic activity.

Instead of 16S rRNA and QPCR, BiomeFx™ uses whole genome sequencing. Instead of targeting one specific gene region, such as the 16S region, this thorough approach gathers a more complete picture by using multiple, overlapping gene primers. A recent study found that whole genome sequencing identified nearly twice as many bacterial species compared to 16S methods, providing more information on microbial richness and diversity (4). This is a stunning finding as individuals using 16S methods may receive faulty dietary and lifestyle advice in response to these testing methods. Whole genome sequencing is far superior and allows clinicians to more accurately provide interventions to heal and balance the gut.

Moreover, BiomeFx™ is distinct from other stool tests because of its unique coring method, which increases the accuracy of samples. Rather than taking a sample from the surface of the stool, this approach gathers data from the core of the sample and presents the findings into a functional report. This functional report will look at microbial trends and patterns to understand what the gut microbiome is doing rather than presenting the data in a meaningless range of high to low. These common reports are confusing, unhelpful, and not backed by scientific research. BiomeFx™ is the superior stool test on the market because of its coring method stool sampling, highly accurate whole-genome analysis and practical, user-friendly reporting.

Shipping Information: If you reside in New York State, please note test kits can not be shipped to your state directly. They can be shipped out of New York but shipments can only be accepted outside the state. This is due to state regulations. Additionally, the BiomeFx test kit is only available domestically within the United States at this time.

Your purchase includes the following: