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Interested in a First-Line Immune Defense?

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It is suggested that overseas travelers using elderberry for 10 days before traveling and up to 5 days after arriving experienced a 2-day shorter duration of the cold (on average), along with noticing a reduction in symptom severity according to a research study performed in Australia [36].

Immune Charge+Background

Immune Charge+™ is a unique blend of vitamins C, A, D, E, K1, K2 and elderberry (Sambucus nigra) packaged in small 100 ml bottles for flexible dosing to help build resiliency against unexpected health challenges. Quicksliver Scientific offers unparalleled liposomal technology which improves the formulas overall bioavailability. In addition to its immune boosting ingredients, Immune Charge+ offers additional benefits such as boosting white blood cell production [16,30] and reducing cold symptoms and duration[36].

Supplement Ingredients

Immune Charge+ is formulated to strengthen the immune system  while shielding the body from health-compromising threats. Containing six power vitamins – A,C, D, E, and K (K1 & K2) – the blend is further amplified with plant based immune support by including Haschberg Elderberry. This fast-acting immune support supplement aids your natural defenses as soon as it hits the tongue.

Vitamin C

Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C also enhances barrier integrity of lung, gut and skin epithelial cells which is the first line of defense against microbial invaders [1,16,17] These invaders are often responsible for respiratory infections like the cold and flu.

Both bacterial and viral infections trigger the production of free radicals by immune cells. Although free radicals serve a primary beneficial purpose they can cause undue harm. Vitamin C reduces the pathogen-induced free
radical damage by protecting cells while the rest of the immune system works to eliminate infection.

Vitamin A

Vitamin A maintains epithelial barriers in the human body, including the epithelial lining of the lungs and the gut mucosa, where a significant portion of the immune system resides[17,18] Vitamin A also supports immune homeostasis by activating immune cells when they are needed to combat infectious threats while attenuating excessive inflammation[23].

Vitamin D

Vitamin D modulates both the innate and adaptive immune responses to respiratory viruses [25].  In the presence of viral infection, lung epithelial cells convert inactive vitamin D into the active form, increasing the expression of a peptide called cathelicidin, which has antiviral effects. Vitamin D also modulates the immune response to respiratory viruses and protects the lungs from damage caused by pro-inflammatory LPS [26,27].

Vitamin E

Vitamin E is a fat-soluble antioxidant that protects the polyunsaturated fatty acids in cell membranes from oxidative damage, which can be triggered by microbial infections. It increases white blood cell proliferation, immunoglobulin levels, natural killer (NK) cell activity, and antibody activity, thus supporting broad-spectrum immune function [28,29].

Quicksilver Scientific utilizes DeltaGOLD® tocotrienols, which offer fifty times the antioxidant activity of tocopherols – the form of vitamin E used in most competitors supplements [30].

Vitamin K1 & K2

Vitamins K1 and K1 are fat-soluble vitamins that work synergistically with vitamins A, D, and E to support healthy immune function. Vitamin K1 (phylloquinone) has anti-inflammatory properties through inhibition of the NF-κB pathway [31]. Vitamin K2 modulates the immune system, decreasing immune reactivity and helping to manage the inflammatory response [32].

Elderberry

Haschberg is a variety or European black elderberry, known for its high potency in anthocyanin flavonoids. Elderberry has direct antiviral activities, demonstrating mild inhibitory effect at the early stage of viral infection and a considerably stronger response in the later stages of infection [33]. Additionally, elderberry exerts antiviral effects by blocking the function of hemagglutinin (HA) glycoproteins present on the surface of viruses, such as the influenza virus and coronaviruses. When the binding of these spikes to host cells is inhibited, viruses can’t enter the host cell to replicate and cause infection [34].

Indications

  • Common cold and flu symptoms

  • Seasonal Allergies

  • Frequency and duration of upper respiratory illness

Advantages of Immune Charge+™

  • Immune Intensive – Can be taken for regular or intensive use as directed by your healthcare practitioner. Includes a powerful 2 mg vitamin C, 10,000 IU vitamin D, 25,000 IU vitamin A per shot to support a healthy immune response.[46]
  • Support Respiratory Health – Vitamin C helps support lung and respiratory health. Vitamin E helps safeguard delicate cell membranes. [46]
  • Support Immune Defenses – In traditional herbalism, elderberry has been used to support immune defenses and common health disruptions. [46]

Suggested Use

Regular Use: Take 1 shot daily for up to 10 days. Thereafter, take up to 4 shorts per week or as directed by your healthcare professional. 

Intensive Use: Take 1 shot, twice daily for up to 5 days.  Thereafter, take up to 4 shorts per week or as directed by your healthcare professional. 

Directions for Use: Hold in mouth 30 seconds before swallowing. Take on an empty stomach, at least 10 minutes before meals. Use individual bottles within 60 days of opening.

Caution: If pregnant, breastfeeding, or planning to become pregnant, consult your physician before use.

Refrigerate after opening if the contents in the container are not used (example: smaller serving sizes). Store unopened containers at room temperature.

Duration

Immune Charge+ can be taken on a consistent basis of up to 4 shots per week, or as directed by you healthcare professional. The intensive use instructions can applied during times of stress, cold and flu season to strengthen the immune system.

Contraindications

Individuals take blood thinning medication should consult with their health practitioner prior to taking this supplement due to possible interactions with Vitamin K1 & K2. There have been no reported contraindications for use of Immune Charge+. 

Clinical Research & Supporting Research Studies

  1. Carr AC and Maggini S. Vitamin C and immune function. Nutrients. 2017; 9(11).
  2. Reshi ML, et al. RNA viruses: ROS-mediated cell death. Int J Cell Biol. 2014; 2014: 467452.
  3. Ware HH, et al. Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections. PLoS One. 2019; 14(2): e0208216.
  4. Lin X, et al. The influenza virus H5N1 infection can induce ROS production for viral replication and host cell death in A549 cells modulated by human Cu/Zn superoxide dismutase (SOD1) overexpression. Viruses. 2016; 8(1): 13.
  5. Pehlivan FE. Vitamin C: An antioxidant agent. Intech Open. 2017; DOI: 10.5772/intechopen.69660.
  6. Lenton KJ, et al. Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency. Am J Clin Nutr. 2003; 77(1): 189-195.
  7. Diotallevi M, et al. Glutathione fine-tunes the innate immune response toward antiviral pathways in a macrophage cell line independently of its antioxidant properties. Front Immunol. 2017; 8: 1239.
  8. Atherton JG, et al. The effect of ascorbic acid on infection of chick-embryo ciliated tracheal organ cultures by coronavirus. Arch Virol. 1978; 56: 195-199.
  9. Davelaar FG and Bos J. Ascorbic acid and infectious bronchitis infections in broilers. Avian Pathol. 1992; 21(4): 581-589.
  10. Hemila H and Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999; 3(9): 756-761.
  11. Silva da Costa L, et al. RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Cell Death & Dis. 2019; 10: 346.
  12. Tisoncik JR, et al. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012; 76(1): 16-32.
  13. Sang X, et al. Vitamin C inhibits the activation of the NLRP3 inflammasome by scavenging mitochondrial ROS. Inflammasome. 2016; 2(1): [online].
  14. Davis JL, et al. Liposomal-encapsulated ascorbic acid: Influence on vitamin C bioavailability and capacity to protect against ischemia-reperfusion injury. Nutr Metab Insights. 2016; 9: 25-30.
  15. Kim Y, et al. Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of Influenza A virus (H3N2) infection. Immune Netw. 2013; 13(2): 70-74.
  16. Mousavi S, et al. Immunomodulatory and antimicrobial effects of vitamin C. Eur J Microbiol Immunol (Bp). 2019; 9(3): 73-79.
  17. Huang Z, et al. Role of Vitamin A in the immune system. J Clin Med. 2018; 7(9): 258.
  18. Timoneda J, et al. Vitamin A deficiency and the lung. Nutrients. 2018; 10(9): 1132.
  19. McGill JL, et al. Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves. Sci Rep. 2019; 9: 15157.
  20. Mawson AR. Role of fat-soluble vitamins A and D in the pathogenesis of influenza: A new perspective. Int Schol Res Not. 2013; 246737.
  21. West CE, et al. Epithelia-damaging virus infections affect vitamin A status in chickens. J Nutr. 1992; 122(2): 333-339.
  22. Cui D, et al. High-level dietary vitamin A enhances T-Helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice. J Nutr. 2000; 130(5): 1132-1139.
  23. Erkelens MN and Mebius RE. Retinoic acid and immune homeostasis: A balancing act. Trends Immunol. 2017; 38(3): 168-180.
  24. Lin R. Crosstalk between Vitamin D metabolism, VDR signalling, and innate immunity. Biomed Res Int. 2016; 2016: 1375858.
  25. Greiller CL and Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015; 7(6): 4240-4270.
  26. Hansdottir S, et al. Respiratory epithelial cells convert inactive vitamin D to its active form: Potential effects on host defense. J Immunol. 2008; 181(10): 7090-7099.
  27. Xu J, et al. Vitamin D alleviates lipopolysaccharide‑induced acute lung injury via regulation of the renin‑angiotensin system. Mol Med Rep. 2017; 16(5): [online].
  28. Serbinova E, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991; 10(5): 263-275.
  29. Ren Z, et al. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 2010; 140(7): 1335-1341.
  30. Lee GY and Han SN. The role of vitamin E in immunity. Nutrients. 2018; 10(11): 1614.
  31. Hodges SJ, et al. Anti-inflammatory actions of vitamin K. Intech Open. 2016; [online].
  32. Halder M, et al. Vitamin K: Double bonds beyond coagulation insights into differences between Vitamin K1 and K2 in health and disease. Int J Mol Sci. 2019; 20(4): 896.
  33. Torabian G, et al. Anti-influenza activity of elderberry (Sambucus nigra). J Funct Foods. 2019; 54: 353-360.
  34. Dolin R. Resistance to neuraminidase inhibitors. Clin Infect Dis. 2011; 52(4): 438-439.
  35. Hawkins J, et al. Black elderberry (Sambucus Nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019; 42: 361-365.
  36. Tiralongo E, et al. Elderberry supplementation reduces cold duration and symptoms in air-travelers: a randomized, double-blind placebo-controlled clinical trial. 2016; 8(182): [online].
  37. Krawitz C, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011; 11: 16.
  38. Simonyi A, et al. Inhibition of microglial activation by elderberry extracts and its phenolic components. Life Sci. 2015; 128: 30-38.
  39. Ho GTT, et al. Elderberry and elderflower extracts, phenolic compounds, and metabolites and their effect on complement, RAW 264.7 macrophages and dendritic cells. Int J Mol Sci. 2017; 18(3): [online].
  40. Lavefve L, et al. Berry polyphenols metabolism and impact on human gut microbiota and health. Food & Funct. 2020; 1: [online].
  41. Khomich OA, et al. Redox biology of respiratory viral infections. Viruses. 2018; 10(8): 392.
  42. Strugala P, et al. A comprehensive study on the biological activity of elderberry extract and cyanidin 3-O-glucoside and their interactions with membranes and human serum albumin. Molecules. 2018; 23(10): 2566.
  43. Ahn H, Park JH. Liposomal delivery systems for intestinal lymphatic drug transport. Biomater Res. 2016; 20: 36.
  44. Alyautdin R, et al. Nanoscale drug delivery systems and the blood-brain barrier. Int J Nanomedicine. 2014; 9: 795-811.
  45. Spector AA, et al. Membrane lipid composition and cellular function. J Lipid Res. 1985; 26(9): 1015-1035.
  46. Source: Quicksilver Scientific, Product Page: https://www.quicksilverscientific.com/all-products/immune-charge-box/

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