Mega IgG2000 is a dairy-free immunoglobulin concentrate that supports healthy digestion and maintains healthy gut barrier function for better gut health. 

 

Background 

Immunoglobulin G (IgG), the most abundant antibody in the system, can be found in blood and extracellular fluid, allowing it to control infections in the body. IgG antibodies can bind a variety of pathogens, including bacteria, viruses, and fungi, as well as their toxic by-products.1 Binding these toxins will neutralize them and allow the immune system to safely remove them from the body. IgG and other antibodies are commonly found in human and other animals’ colostrum, or early breastmilk.

Ingredients

Mega IgG 2000 contains pure serum-derived bovine immunoglobulin (SBI) protein concentrate in a vegetarian capsule. Unlike other milk-derived immunoglobulins on the market, Mega IgG2000 is derived from bovine serum, making it lactose-free, casein-free, and β-lactoglobulin-free.

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Function

This dairy-free immunoglobulin concentrate supports healthy digestion, neutralizes environmental toxins, and helps to rebuild protective intestinal barriers.2 These IgG antibodies can reduce the damage of metabolic endotoxemia and neutralize LPS, an endotoxin that triggers mucosal activation. 

This unique alternative to bovine colostrum supports a healthy mucosal immune system by decreasing unfavorable immune activation in the mucosal layer, lowering toxic burden and strengthening gut barrier function.1,2 

When an antigen enters the body, it elicits a response from the innate and adaptive branches of the immune system. The adaptive immune response utilizes B and T lymphocytes to find foreign antigens, neutralize them, and eliminate them from the body. B lymphocytes do this by producing antibodies, or immunoglobulins, that can bind to unwanted antigens and remove them from the system.

LEFT SIDE: Free-flowing antigens that reach the epithelial lining can trigger mucosal activation and inflammation. RIGHT SIDE: IgG antibodies bind and neutralize these antigens before they can trigger mucosal and intestinal inflammation.

Main Functions:

• Immune Support – reduces inflammation and intestinal damage
• Healthy Metabolism – improves nutrient digestion and absorption
• Mucosal Defense – maintains healthy mucosal barrier function in the digestive tract

Mega IgG2000 can bind a variety of different toxins and whole bacteria, making it very effective at improving gut infections. 

Research

The SBI in Mega IgG2000 has been used in so many published studies that it will be easier to review in a table format.

Study	Subjects	Variables Studied	Outcome
Antigen-Binding Capacity
Detzel CJ, Horgan A, Henderson AL, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015;10(4):e0120278.	Caco-2 cell line study	Antigen binding	SBI may reduce pro-inflammatory cytokine production via antigen binding
Irritable Bowel Syndrome
Shaw, et al. Impact of serum-derived bovine immunoglobulin/protein isolate therapy on irritable bowel syndrome and inflammatory bowel disease: a survey of patient perspective. Patient Preference and Adherence 2017; 11: 1001-1006.	595 patients with IBS	stool frequency, symptom management, and QOL	SBI improves symptoms of IBS in adults
Dlugosz A et al. Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 2015; 27(12): 1747-54.	194 adults	Serum LPS, anti-flagellin IgG antibodies	Higher LPS and anti-flagellin antibodies were associated with IBS-D.
Good L, Shaw A, Wei D, et al. Oral serum bovine immunoglobulin improves IBS-D symptoms analyzed from patient medical charts. Biol Med Case Rep. 2017;1(1):16-23.	165 IBS-D patient medical charts	Abdominal pain, stool frequency, stool consistency	SBI improves symptoms of IBS in adults, improves QOL
Weinstock LB and Jasion VS. Serum-Derived Bovine Immunoglobulin/Protein Isolate   Therapy for Patients with Refractory Irritable Bowel Syndrome. Open Journal of Gastroenterology. 2014; 4:329-334.	35 adults with IBS	Abdominal discomfort, bloating and flatulence	SBI is an effective form of nutrition therapy for IBS patients
Wilson, et al. Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome. Clinical Medicine Insights: Gastroenterology. 2013:6 49–60	30 patients with IBS	Abdominal pain, stool consistency, bloating, gas, urgency and other IBS symptoms	Nutritional therapy with either 10 g/day or 5 g/day of SBI in 30 patients was well tolerated and improved IBS symptoms
Wilson D, et al. Serum-Derived Bovine Immunoglobulin (SBI) for Children with Diarrhea Predominant Irritable Bowel Syndrome (d-IBS). Clin Med Insights Gastroenterol 2013; 6:49-60.	20 children with IBS	Stool frequency, abdominal pain, stool form	SBI improve symptoms of IBS-D in children
Wilson D, Evans M, Weaver E, Shaw AL, Klein GL. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49–60.	15 adults	GI symptom scores	SBI decreases abdominal pain, flatulence, bloating, urgency, loose stools, and duration of IBS-related symptoms
Valentin et al. Potential mechanisms of effects of serum-derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea-predominant irritable bowel syndrome. Physiol Rep. 2017; 5(5): e13170.	15 IBS patients	Intestinal permeability, microbial abundance and diversity	SBI therapy for 8 weeks in IBS-D patients is associated with improved bowel function.
Good, L. et al. New therapeutic option for irritable bowel syndrome: Serum-derived bovine immunoglobulin. World J Gastroentero.l 2015 March 21; 21(11): 3361-3366	14 IBS patients	Stool consistency,   abdominal pain, bloating, distention, and incontinence	SBI reduces symptoms of IBS in as little as 4 weeks, with further improvement of symptoms with continued use
Hilal R, Mitchell P, Guerra Jr E, and Burnett BP. Case Series of 10 Drug-Refractory IBS Patients Who Respond to Oral Serum-Derived Bovine Immunoglobulin/ Protein Isolate (SBI). Open Journal of Gastroenterology. 2014; 4: 321-328.	10 IBS patients	Abdominal pain, stool frequency and consistency	SBI resulted in the near complete management of IBS in all 10 patients. Symptoms improved in 2-4 weeks
Crawford C, et al. Oral serum-derived bovine immunoglobulins for post-infectious IBS. Gastroenterology and Hepatology Research. 2015; 4(4): 1577-1581	2, case study	C diff infection recurrence, stool frequency and consistency	SBI reduces, or completely eliminates recurrent C. diff infection in IBS patients, increasing QOL
Inflammatory Bowel Diseases
Shafran et al. Management of inflammatory bowel disease with oral serum-derived bovine Immunoglobulin. Therapeutic Advances in Gastroenterology. 2015; 8(6):331-9	83 IBD patients	IBD symptoms, disease regression	SBI improves clinical management of IBD patients who   are not fully managed on traditional therapies.
Good L, Panas R. Case Series Investigating the Clinical Practice Experience of Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI) in the Clinical Management of Patients with Inflammatory Bowel Disease. Journal of Gastrointestinal &Digestive System. 2015; 5(2): 1-5	7 (UC) and (CD) patients	Colon permeability, cytokine production, microbial composition	SBI significantly improves symptoms of IBD
Shafran et al. Pilot Pharmacoeconomic Analysis of Serum-derived Bovine Immunoglobulin Use in IBD. Am J Pharm Benefits. 2016;8(2):e34-e41	7 IBD patients	Biologic therapy use, cost of IBD treatment	SBI is an effective therapy for IBD, and is associated with significant yearly savings on IBD treatment
Awad A, Jasion VS. Use of a Nutritional Therapy, Serum-Derived Bovine Immunoglobulin/Protein Isolate (SBI), to Achieve Improvement in Two Different Cases of Colitis. J Gastrointest Dig System. 2015; 5: 274.	2 IBS patients, case studies	Cytokine production, stool consistency/frequency, cramping, incontinence	2.5-5 QD of SBI significantly improved symptoms of ulcerative colitis
Gelfand, et al. Oral Serum-Derived Bovine Immunoglobulin for Management of Infectious Diarrhea due to Norovirus   and Cryptosporidiosis in Solid Organ Transplant Patients. Infectious Diseases in Clinical Practice. 2017; 25(4):218-220.	2 patients, case study	Diarrhea incidence	SBI improved symptoms of infectious diarrhea, in as little as 3 days
Soriano et al. Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with   Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen. Case Reports in Gastroenterology. 2017; 1:1-7.	1 pediatric UC patient, case study	Intestinal inflammation, abdominal symptoms, blood in stool, and   diarrhea	SBI supplementation significantly reduced symptoms of UC within 2 months
Good and Burnett. Management of Loose, Frequent Stools and Fecal Incontinence in a Chronic Mesenteric Ischemia Patient with Oral Serum-derived Bovine   ­Immunoglobulin. Clinical Medicine Insights: Gastroenterology 2015:8 7–11	1 patient, case study	Stool consistency, frequency, abdominal pain, nocturnal stool, QOL, urgency	Safe, nutritional therapy offers relief of symptoms for people with FI in patients with CMI in this difficult to manage gastrointestinal population.
Beauerle et al. Successful management of refractory ulcerative colitis with orally administered serum-derived bovine immunoglobulin therapy. Clin Case Rep Rev. 2015; 1(4): 90-92.	1 UC patient, case study	C. diff infection recurrence, stool frequency/consistency, histologic improvement, Mayo UC score	5g  SBI daily vastly improves symptoms of UC
HIV Enteropathy
Asmuth et al. Evaluation of oral bovine immunoglobulins in HIV participants. HIV Clinical Trials. 18(5-6): 205-213.	103 HIV positive participants	HIV-related GI symptoms, such as diarrhea, incontinence and frequency of stool	Oral SBI is safe and well-tolerated in HIV patients with chronic diarrhea.
Asmuth DM, Ma ZM, Albanese A, et al. Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. AIDS. 2013;27(14):2207–2217.	8 adults	CD4+ lymphocyte, stool consistency, and intestinal-fatty acid binding protein (I-FABP)	SBI significantly increases intestinal mucosal CD4+ lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in HIV enteropathy.
Asmuth et al. Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. AIDS. 2013; 27(14): 2207-2217.	8 HIV positive patients	Gut permeability and inflammation, stool consistency and frequency	SBI significantly increases intestinal mucosal CD4þ lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in the setting of HIV enteropathy.

Indications

Autoimmune conditions

Gut infections

Seasonal or food allergies

Food sensitivities

Acute stress or illness

Advantages

Supplemental immunoglobulins are only available from two sources: serum and colostrum. Most immunoglobulin supplements are sourced from colostrum as it is more cost-effective, but colostrum also contains about 25% IgG immunoglobulins in addition to lactose. In some cases, colostrum can also contain soy isoflavones, dairy proteins like casein or whey, and toxins.

Serum-derived bovine immunoglobulins (SBI) contain over 45% IgG immunoglobulins and are free of other contaminants like pus, lactose, dairy proteins, and soy isoflavones. Mega IgG2000 has a higher concentration of IgG immunoglobulins boasts the highest purity of any immunoglobulin supplement on the market.

Suggested Use

Ages 2+. Take 4 capsules daily with or without a meal, or as directed by your healthcare professional. Capsules may be opened, and powder may be mixed into food or drink. Mega IgG2000 is safe to take while pregnant and/or nursing. 

Hydration is highly encouraged when taking Mega IgG2000. When the immunoglobulins bind toxins, your body clears them from the system by excreting them in the feces. This can lead to more fecal bulking, similar to taking a fiber supplement. If you are too dehydrated, the immunoglobulins can cause stools to be harder than usual. Increasing your intake of water can resolve this problem quickly.

Synergy

Mega IgG2000TM can be very effective when taken alongside MegaSporeBioticTM, MegaMycoBalanceTM, or any antimicrobial that might increase the release of toxins in the gut. Since Mega IgG2000TM can effectively bind and neutralize a variety of toxins, taking it when starting the aforementioned products can help reduce the frequency and occurrence of common die-off symptoms.

Duration

MegaIgG2000TM can be taken indefinitely to reduce the toxic load on the liver, or taken as needed during times of stress, cold and flu season, or when dining out in order to strengthen the immune system.

Contraindications

These immunoglobulins are derived from the serum of cows and may not be suitable for vegans or individuals adhering to various religious traditions.

References

1. Detzel CJ, Horgan A, Henderson AL, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS one. 2015;10(4):e0120278. 
2. Perez-Bosque A, Miro L, Maijo M, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. American journal of physiology Gastrointestinal and liver physiology. 2015;308(12):G1012-8.