Support Healthy Yeast and Fungal Balance in the Body.

What Are Probiotics?

Our ancestors had a diet brimming with nutrients and beneficial species of live bacteria because they lived off the land. These species of live bacteria evolved into an essential component of our digestive system known as probiotics. Probiotics regulate the digestive system, improve immune function and serve as the first line of defense against infections.

What if I Don’t Take Probiotics?

Digestive health is paramount to our overall health. An unhealthy digestive system results in an over-growth of bad bacteria and yeast. Food cannot be broken down properly, essential nutrients are not absorbed and the immune system is compromised leaving us fatigued and rundown. Over-growth of bad bacteria leads to a higher risk of infections, allergies, and inflammation, which can lead to symptoms of constipation, diarrhea, gas, bloating, acid reflux disease, eczema and often weight gain.

What Kind of Probiotic Should I take?

Not all probiotics are created equal. For a probiotic to perform its necessary function, it must naturally survive the stomach’s harsh environment and arrive to the intestines alive. A true probiotic, designed by nature, is a species found in our environment, as well as in our digestive system. Over 95% of probiotic products in the marketplace today do not meet these criteria. To date, the most researched and widely used true probiotic strains are from the bacillus species. MegaSporeBiotic contains strains that have been proven to impede the growth of unwanted bacteria and yeast, while strengthening the immune response and producing essential nutrients at the site of absorption. MegaSporeBiotic is the first probiotic and antioxidant combination sold exclusively through health practitioners.
DISCLAIMER: *These statements have not been evaluated by the Food and Drug Administration

Buy MegaMycoBalance™

MegaMycoBalance™

$44.00

MegaMycoBalance is formulated with undecylenic acid and bee propolis to support healthy yeast and fungal balance in the body.

MegaMycoBalance™

Designed by Nature

MegaSporeBiotic™ is formulated with nature in mind. Spores, derived from the word “seed,” are the most basic building block of a new cell. Found naturally in our environment, spores are a robust and effective way of delivering probiotics. Once they reach the intestines, they go to work strengthening the immune system and protecting you from infection.

Stomach Survivor

Our scientists have found a way to deliver these probiotics safely to the digestive system. These strains have a tough natural outer shell that protects them from the stomach acid. This key feature is what makes MegaSporeBiotic™ effective and what separates us from all other probiotic products.

Antioxidant Benefits

MegaSporeBiotic™ introduces HU36™, the first commercially available carotenoid rich probiotic. This strain naturally produces forms of lycopene, astaxanthin, zeaxanthin, beta carotene and lutein in your digestive tract right at the site of absorption. This makes them the most bioavailable antioxidants known to science.

No Refrigeration – Convenient

Traveling with MegaSporeBiotic™ is convenient, uncomplicated, and practical because it does not require refrigeration. If a probiotic is so fragile it requires refrigeration, how will it survive the high temperatures and acidity of the stomach? It won’t. MegaSporeBiotic™ survives and arrives at the site of colonization alive, so it can perform its probiotic function!
DISCLAIMER: *These statements have not been evaluated by the Food and Drug Administration

What can MegaMycoBalance do for you?

  • Supports yeast and fungal balance in the gut and body
  • Supports a healthy balance of vaginal flora by restoring balance to the intestinal flora
What can MegaSporeBiotic do for you?

Frequently Asked Questions?

What is MegaSporeBiotic?

MegaSporeBiotic is the first, All Spore, pharmaceutical grade probiotic product that takes advantage of nature’s design for a perfect and true probiotic. Physicians Exclusive has identified key spores as both safe and effective at supporting digestive health and boosting immunity. Physicians Exclusive is making these spores available for the first time in the dietary supplement industry. MegaSporeBiotic is the first dietary supplement probiotic that contains 5 proven pharmaceutical grade bacillus spores including the patented carotenoid rich probiotic strain – B. indicus HU36.

What is a probiotic?

Probiotics are the fastest growing category in the supplement industry. Recent research done by the NIH has defined probiotics by a strict criteria:

1. The organism must be a normally occurring organism in the digestive tract.
2. In order to consistently trigger a healthy boost in immune function the organism must be supplemented in concentrations higher than what normally occurs in the digestive tract.
3. The organism must be able to survive in the digestive tract as well as in the environment.
Interestingly enough there are almost no probiotics in the marketplace that meet all three of these criteria!

I am currently taking a probiotic and it seems to be working just fine. Why should I switch to MegaSporeBiotic?

MegaSporeBiotic offers functions that other common probiotics do not. Effective probiotics go beyond digestive health. Effective probiotics are critical for immune function, immune stimulation, managing populations of dangerous bacteria, digestion of cholesterol, neutralizing toxins, production of key nutrients, etc. Unless your current probiotic contains high doses of several spore strains, it is not providing all these beneficial affects. Use MegaSporeBiotic to take complete advantage of all the functions of a true probiotic.

What is the shelf life of MegaSporeBiotic?

2 Years, the expiration date will be indicated on the box.

Any significance of taking after a meal? What about if on an empty stomach?

Yes. The amino acids and carbohydrates in food help the spores move from their dormant (spore state) to their active (vegetative state) form in the GI. There are tremendous immune benefits if the spores are made to germinate into their vegetative state in the upper GI itself and so taking just after a meal (10-20 mins after) is ideal.

So, Greek yogurt does not work? Where do you get the good products for your patients?

Unfortunately yogurts and yogurt based drinks (including Kefirs) don’t work as probiotics in our experience and research. There are some benefits from the fermentation process and those benefits are contained in the product in the form of micro-nutrients. But those strains used in yogurts and other fermented dairy products, do not have the ability to survive the harsh stomach and colonize in the GI. For a true probiotic, we only work with MegaSporeBiotic.

How do you know what to give patients and for what conditions?­

Health in general starts in the gut. Hippocrates said it in 400 B.C. and since then modern science has proven it. Any immune dysfunction (auto-immune, allergies, food sensitivities, rashes, psoriasis, eczema, rheumatoid arthritis, gout, etc.) can be traced back to a dysfunction in the GI. Any inflammatory condition can as well. Now, modern science has shown us that weight control, mood, depression and other mental disorders are also connected to the gut (the second brain). Even chronic diseases such as diabetes, heart disease, cancer, etc. can be traced back to the gut. Everything starts in the GI. With that in mind, all your patients should be on a daily dose of this probiotic as well as a diet that supports a healthy flora. It’s as essential as any multivitamin, greens drink or fish oil product that people may use as part of their daily nutrition. So start all patients on it and nearly everyone (despite their condition or ailment), will see some benefit as you are now replacing an essential nutrient that has been missing from their diet. For patients that present with a strong yeast issue or those with strong inflammatory conditions (Crohn’s, IBD, Ulcerative colitis, etc.) should titrate the dose up slowly. Starting with 1 cap every other day for a week or until they can tolerate, then 1 cap per day using the same discretion and finally 2 caps per day. Symptoms to watch out for include intestinal cramping and diarrhea.

How is your product different from Lactobacillus sporogenes by thorne­?

Lactobacillus Sporongenes is a mislabeling of Bacillus Coagulans. We will refer to the product under its correct name which is bacillus coagulans. Bacillus coagulans is a spore former with the benefits we talked about with our product, in fact, we also have bacillus coagulans in our formulation as one of the 5 strains. There are however some very important differences between MegaSporeBiotic and the Bacillus Coagulans product from Throne, they are as follows:

1) We are verified to be in 100% spore form – this is critical as spore formers are also unable to survive the journey to the intestines unless they are in spore form. From what we have seen, other products that may contain 1 or 2 spores have only some of those strains in spore form; the rest is in vegetative cell form. This makes them less effective.

2) We have 5 critical strains that work in synergy. These bacillus spores aren’t found by themselves in nature. In nature these spores are typically in co-existence with other bacillus spores and they support one another in the human body. Having an effective consortium of the right spores is more how nature intended. In addition, these various spores perform different functions in the body. Having just 1 of the strains means at least 1/5 less function.

3) With 5 strains you get a whole spectrum of nutrient production that you won’t see with just 1 strain. Between the 5 they produce the whole spectrum of B vitamins, quinols, vitamin K2, digestive enzymes, etc. Each of the strains produces a different set of micronutrients.

4) Lastly, ours contains the patented bacillus indicus HU36 – this is the world’s first carotenoid (antioxidant) rich probiotic. This strain colonizes in the GI and produces RDA levels of carotenoids right at the site of absorption.

Can probiotics or spore probiotics be safely taken when breast feeding or pregnant­?

Yes, we have a number of patients and individuals who are taking the product during pregnancy and nursing. If the pregnant or nursing mother has strong inflammatory conditions or yeast issues, they should also be titrated up so there isn’t a detox reaction.

What test do you recommend for stool – flora evaluation­?

Comprehensive Digestive Stool analysis is the best way to evaluate the composition of Flora in the bowel.

What are the actual number results from GI study of all the carotenoids, vit K2, etc.?­

In the GI study we focused on the caroteniods in terms of being able to enumerate the quantities produced and absorbed. We did not focus on the vitamins and enzymes. The study showed that on average, after 3-4 weeks of daily use, the strain was producing roughly 800ug of carotenoids per day. These carotenoids are produced right at the site of absorption and are thus roughly 10 times more bioavailable than standard, supplemented carotenoids. The researchers concluded that it reaches the Recommended Daily Allowance of carotenoids.

Are you working on a spore type product for fecal transplanting?

No, it’s not necessary to administer spores in that manner. There are 2 main reasons why fecal transplants can be effective; 1) you can administer a high enough dose of the lactobacillus and bifidobacterium species and 2) you are not passing through the harsh gastric barrier, thus they can survive to reach the intestines.

Spores can already survive the harsh gastric barrier and can be supplemented in effective dosages per oral dosing, thus they don’t need to be administered through the rectum.

What Conditions are specific for MegaSporeBiotic?

Clinically, we have benefitted the following conditions and other doctors have reported major benefits in these listed conditions as well:

Crohn’s, IBS, IBD and colitis
– Minor and major gastro discomfort – gas, bloating, indigestion
– Acid reflux/GERD
– Hashimoto’s disease
– Cystic acne
– Rheumatoid arthritis
– Allergies, asthma, eczema, psoriasis.

Will the spores still work if you pull the pill apart and still take it?

Absolutely. This is the preferred way to administer to children. It can be pulled apart and the powder mixed into nearly any food or drink. It is temperature stable, so it can even be mixed into hot tea, coffee or soup. There is no real taste impact of the powder.

When using MegaSporeBiotic, is dosing once per day or more often depending upon clinical presentation of the patient?

The product should always be dosed once per day only. There is no need or benefit in splitting the dose to 2 or more per day or doubling the dose of 2 capsules. You want to get the full dose of probiotics in at once. This again is best about 10-20 minutes after a meal.

I would also like to know if Propioni bacterium acnes t6 is available for use?­

We do not carry Propionibacterium acnes

Would like to know your view on vsl#3 and Saccharomces Boulardii? And the use of Lactoferrin?

VSL 3 is a probiotic formulation that uses the same rationale as 95% of probiotics out in the market place. It uses 8-10 strains of various lactobacillus and bifidobacterium species but has focused on formulating the largest numbers of these strains – in one of their formulations they claim nearly 900 Billion CFU. In our opinion, it is an enhanced version of many probiotics found in the market today. It may have some effect on acute symptoms, but we would not feel comfortable saying that it performs as a “probiotic” per the World Health Organization definition.

Saccharomyces boulardii is a strain we like and we believe is effective. In fact, we have used it ourselves. It fits natures design as a probiotic and the scientific definition as well. It is however a probiotic fungus and not a bacteria. Although it can be effective against diarrhea, it has limited function. To use it by itself as a daily probiotic is incomplete therapy. We use MegaSporeBiotic and supplement from time to time with S. boulardii in cases of severe and acute diarrhea.

Lactoferrin is an immune component that can be useful for acute infections or conditions. It’s not designed to be used chronically. If you look in nature, the highest concentration of lactoferrin is found in human colostrum, then the concentration reduces in human milk. Colostrum only comes in the first few days after birth and then milk comes in where nature has designed for the lactoferrin concentration to reduce. Of course the milk eventually stops as well and so humans have not evolved to require or use lactoferrin their entire life. Its important to establish the innate immune system in newborns and to protect the newborn from infection as newborns are not producing their own immune cells and then it becomes less important as the newborn matures and starts to produce its own innate immunity components. The strains in MegaSporeBiotic are a potent immune modulator and they do this equally for children and adults. In fact, it has been shown that our immune systems are likely designed with a need for this daily stimulation and modulation by bacillus spores. This would not be surprising from an evolutionary stand point when you consider that our ancestors got a daily dose of these strains their entire lives.

What is the general length of time needed to get the gut to self-inoculate? I.e. how long do you have to take these spores before you can ease up and survive on your own?

Nature has designed these spores to be a daily, foundational food. They are transient microorganisms, thus they don’t stay in the GI forever. They go in, perform a function and leave. This is important as this helps keep their numbers in the GI relatively low which means each dose has an effect. It takes them about 21 days to reach a steady state concentration in the GI with daily supplementing and at this stage is where they are the most effective in regulating the GI. At this time, it’s important to consume a diet low in refined sugars and higher in fibers to facilitate the growth of the individual’s own good bacteria. In fact, the spores can also increase the growth of the good bacteria. Between the spores being present and the improved diet, the individual will go into a state where they have the right microbiota balance. If the spores are removed, then you are tipping the balance back towards Dysbiosis. The use of the spores on a daily basis is a very important maintenance practice. We are bombarding our GI on a daily basis with things that shift the balance to Dysbiosis and so the spores are required to remain and police our GI.Saccharomyces boulardii is a strain we like and we believe is effective. In fact, we have used it ourselves. It fits natures design as a probiotic and the scientific definition as well. It is however a probiotic fungus and not a bacteria. Although it can be effective against diarrhea, it has limited function. To use it by itself as a daily probiotic is incomplete therapy. We use MegaSporeBiotic and supplement from time to time with S. boulardii in cases of severe and acute diarrhea.

Lactoferrin is an immune component that can be useful for acute infections or conditions. It’s not designed to be used chronically. If you look in nature, the highest concentration of lactoferrin is found in human colostrum, then the concentration reduces in human milk. Colostrum only comes in the first few days after birth and then milk comes in where nature has designed for the lactoferrin concentration to reduce. Of course the milk eventually stops as well and so humans have not evolved to require or use lactoferrin their entire life. Its important to establish the innate immune system in newborns and to protect the newborn from infection as newborns are not producing their own immune cells and then it becomes less important as the newborn matures and starts to produce its own innate immunity components. The strains in MegaSporeBiotic are a potent immune modulator and they do this equally for children and adults. In fact, it has been shown that our immune systems are likely designed with a need for this daily stimulation and modulation by bacillus spores. This would not be surprising from an evolutionary stand point when you consider that our ancestors got a daily dose of these strains their entire lives.

Can pets (cats & dogs) be supplemented with MegaSporeBiotic? ­

Yes, the strains are universal probiotics and are used in all types of animals and livestock throughout the world, including marine life. Take one capsule, pull it apart and sprinkle it on their food.

Any healing crisis that may develop when you first start these and they start killing off yeasts or other pathogens­?

As with any product that is effective in restoring balance to an unhealthy intestinal tract the chance for your patients to experience herxheimer reactions is possible. Because of this we recommend that the dose be titrated up slowly to control detox reactions. The most frequent symptoms reported are intestinal cramping and loose stools. Decreasing dose eliminates any uncomfortable symptoms.

Why is MegaSporeBiotic different from other probiotics already on the market?

MegaSporeBiotic is the only product with 5 pharmaceutical grade bacillus spore strains. In addition, MegaSporeBiotic is the first probiotic to introduce a strain that produces key nutrients in the digestive system. In this case, the nutrients produced are powerful carotenoid antioxidants. Carotenoids are the beneficial antioxidants found in colored fruits and vegetables. Carotenoids from dietary supplements however are poorly absorbed and most people do not eat as many colored fruits and vegetables as they should, thus supplementation with a carotenoid rich probiotic is highly important. These beneficial bacteria produce high levels of carotenoids right at the sight of absorption, thus allowing for optimum uptake into the body. MegaSporeBiotic is the first and only probiotic with such a feature.

What spores are present in MegaSporeBiotic?

MegaSporeBiotic contains 5 pharmaceutical grade strains that each have unique function and thus contribute to the overall effectiveness of the product. Below is a brief description of each:

1) Bacillus Indicus HU36 – The first carotenoid rich probiotic strain offered to the dietary supplement market. An isolate from humans, Indicus HU36 produces high levels of powerful carotenoids (antioxidants) at the site of absorption. Carotenoids do not survive the gastric system well. HU36 however, has demonstrated the ability to survive past the stomach acid and produce the carotenoids at their site of absorption in the gut. This makes the carotenoids produced by HU 36 the most bioavailable supplementary carotenoids in the marketplace. HU36 gives MegaSporeBiotic a function that no other probiotic formulations on the market can claim-it provides key nutrients in their most potent form.

2) Bacillus Clausii – This strain is the largest selling strain of prescription probiotic in the world. For the first time, this strain is made available to the U.S. dietary supplement industry and is available exclusively to healthcare professionals. Bacillus Clausii is recommended for use during antibiotic treatment due to its ability to resist damage from a variety of common antibiotics. MegaSporeBiotic has the unique function of being a powerful supplement that can be used in adjunct with antibiotic therapy to keep the organisms balanced in the gut.

3) Bacillus Subtilis HU58 – Bacillus Subtilis has been extensively studied on a genetic and functional level. There are several probiotic products in the pharmaceutical and agricultural markets that utilize this powerful probiotic. One very interesting function of Bacillus Subtilis is its ability to produce nearly 12 strong antibiotics that are potent fighters of opportunistic and harmful bacteria. Bacillus Subtilis HU58 offers MegaSporeBiotic the ability to prevent harmful bacteria growth in a variety of conditions. In addition, HU58 produces a very healthy compound called Nattokinase. Nattokinase is secreted from vegetative cells of Bacillus subtilis and has been shown to reduce blood pressure, reduce cholesterol and reduce excessive clotting by fibrinolysis. Along with Nattokinase, Bacillus subtilis also produces a number of other nutrients that have systemic health benefits such as B vitamins and Vitamin K2. Bacillus subtilis HU58 offers MegaSporeBiotic the important function of fighting off pathogenic bacteria and producing key nutrients in the gut itself. In addition, HU58 is an extremely potent immune stimulator. It has the function of germinating in the small intestines to some degree and this offers the effect of broad-spectrum immune stimulation.
4) Bacillus Licheniformis – A probiotic often found with Bacillus subtilis and other bacillus species, licheniformis has been shown to have a potent effect of preventing the growth of harmful bacteria via the production of a common antibiotic called bacitracin. It is also a potent immune stimulator. Another very important feature of bacillus licheniformis is its ability to produce highly effective and stable protease enzymes in the gut that assist in the digestion and absorption of proteins. Lastly, licheniformis also produces the whole spectrum of B vitamins in the gut including folic acid and biotin and acts as an important nutrient factory in the digestive system.

5) Bacillus Coagulans – A very well studied probiotic in the spore family that has a profound effect on inflammatory conditions such as IBS and Crohn’s. Bacillus coagulans offers MegaSporebiotic an expanded effect of controlling these common inflammatory bowel conditions in addition to its potent immune boosting activity. Coagulans has the unique attribute of producing lactic acid and specifically the L+ optical isomer of lactic acid, which has been shown to have a more profound effect on immune stimulation and gut defense than the other forms of lactic acid produced by conventional probiotics. Coagulans is also a tremendous colonizer and thus assures proper colonization of MEGAsporebiotic, which in turn will produce the beneficial effects required. Coagulans also plays a key role in digestion of food and absorption of nutrients. In fact, Coagulans can digest incoming fat to reduce the uptake of cholesterol. Coagulans adds another dimension to MEGAsporebiotic, giving it a potent ability to fight inflammatory conditions, aid in digestion and prevent the growth of harmful bacteria.

What are the side effects of taking a probiotic/MegaSporeBiotic?

None have been reported for MegaSporeBiotic.

If a probiotic has no spot to colonize, can it cause problems until it is expelled?

In theory, yes. The bacteria could be seen as an invading species and the body can mount an immune response to it. The response would be a pro-inflammatory innate response which can then harm other tissues in the area as well. It’s important to know that a supplemented probiotic has a place in the individuals microbiota – with bacillus spores being such universal probiotics, you can feel comfortable that they have a spot to colonize every time.

Can live fermented foods colonize the gut effectively? And would these spore probiotics help the SIBO condition, which has been characterized as an overgrowth of good bacteria. Also can candida excess yeast be helped?

Fermented foods are great for the GI, but the benefits don’t typically come from the microorganisms in the food going in and colonizing, it comes from the ferment itself. The many nutrients the bacteria made while fermenting the foods are what helps the GI and the immune system from fermented foods. The problem however is they don’t do much to alter the Dysbiosis one may have in the GI. This is where a true and effective probiotic comes in. MegaSporeBiotic contains one of the only strains that have been shown in studies to actually alter the GI flora when it colonizes. This is a difficult task when you consider that the flora is made up of nearly 100 trillion cells and the probiotic is there in a concentration of just a few billion. But some strains are specialized to do this type of work and our strain bacillus Subtilis HU58 is one such strain.

Another key strain in the formula (bacillus clausii), has been used as a prescription treatment for SIBO for a number of years. It can be very effective in your patients suffering with SIBO.

We have had numerous cases of candidiasis that have seen great benefit from this product. There can be some strange looking excrement for a period of time as the yeast leaves the system, but we have always seen very consistent and positive results.

In the case of dysbiosis would there be a need to reduce the population of the good guys and bad guys before repopulating the GIT?

Yes, you can certainly have too many of certain good guys. In fact, a commensal bacterium in your GI is a “good guy” only until a certain point. Once that “good guy” reaches a certain population level, it can easily become a “bad guy” as in being a problem for the system. This is the issue in SIBO. One of the most profound effects of these bacillus spores in MegaSporeBiotic is their ability to “police” the GI. They facilitate and support the growth of the “good guys” that are under population and can reduce the numbers of the bacterium that are over-grown. They create a modulating effect on the microbiota. Start with MegaSporeBiotic, let these strains regulate the microbiota, then use foods and supplements that support the growth of the good bacteria. Taking the spores daily will ensure that the balance is not lost again.

How I Came To Love MegaSporeBiotic, the World’s Best Probiotic

Never did I think that some tiny spore-forming bacteria would be responsible for radically shifting my professional career or my life. Two years ago, I didn’t even know that such organisms existed.

I was plodding along, moving from one ‘professional-grade’ probiotic product to another, trying to find something that would really help my clients and those who attended classes and workshops that I taught. I understood that our microbiome, the trillions of tiny organisms that make our body home, was extremely important – but I was becoming increasingly frustrated with the lack of consistent positive results after trying at least twenty different brands of the ‘best’ probiotics on the market.

These included, but definitely not limited to: Klaire, Biokult, VSL#3, Innate Response, Designs for Health, Standard Process, Orthomolecular, Theralac, Garden of Life, Custom, and many other very respected, very expensive practitioner-only products.

NOTE: I still use products made by several of these companies, and am definitely not claiming these companies to be misleading, producing poor quality products, or anything of the sort.

This was the spring of 2014 and I was about to give up on probiotic supplements, as a whole – and move more towards only utilizing fermented foods. The problem with this approach, which concerned me, was that at least half of the clients I worked with did very poorly with fermented foods and couldn’t tolerate them at all – which is actually quite common in people with GI infections, overgrowths, inflammation, etc…

Finally, I came across something different. While listening to an episode of Chris Kresser’s (well-known Functional Medicine Practitioner) podcast, I heard him discuss soil-based organisms. The product he mentioned, specifically, was Prescript-Assist. Chris went on to explain that he’d seen better results with these type of organisms, and this product specifically, when compared with his experience using conventional probiotics – which generally consist of various strains of lactobacillus and bifidobacterium. With nothing to lose, I decided to give this product a shot. If nothing else, it was something different than what I’d been doing.

The definition of insanity is doing the same thing over and over again, but expecting different results.
– Albert Einstein

Initially, the results were rather encouraging. More people saw positive results than I had seen with any conventional probiotics, that’s for sure. There were still, however, many people who didn’t do well, or saw nothing at all. The improvements were generally very subtle for most people, if noticeable at all. Yes, it was better… but nothing really spectacular.

That’s when I stumbled upon a webinar titled ‘Forget What You Know About Probiotics‘, directed at practitioners, and hosted by Dr. Thomas Bayne, DC and Kiran Krishnan (Microbiologist) – the founders of Physicians Exclusive and creators of MegaSporeBiotic.

Needless to say, the information presented definitely peaked my interest. It was different, intriguing, and made sense.

I decided to give it a whirl.

Within a few weeks, she was reporting back that her allergies and
asthma were almost non-existent and she felt great.
As mind-blowing as this was, it was about to get even more unbelievable.

The first person I gave the product to was my mother-in-law. She had recently been diagnosed with Hashimoto’s, an autoimmune condition which attacks the Thyroid. Auto-immunity is strongly linked to gut permeability issues, GI inflammation, and gut dysbiosis (wrong bugs). She had also suffered from life-long severe (often requiring hospitalization) asthma and allergies (mainly to pets).

Within a few weeks, she was reporting back that her allergies and asthma were almost non-existent and she felt great. As mind-blowing as this was, it was about to get even more unbelievable. A few weeks later, so maybe 6 weeks after she began taking the spores, she came to visit us. We have a dog and a cat, so previously there is no way she would have even been able to come in our home.

Not only was she able to be in the house, she was able to pet the animals, which is something she hadn’t been able to do in decades without risk of life-threatening reactions. To say this was emotional for her doesn’t do the situation justice. Life-changing is more accurate.I was sold. From there, I started recommending the product to my clients, and in several Facebook groups that I’m in.  One person after another was reporting back to me with rather amazing results, which I honestly wouldn’t have believed a few months prior. Word spread like wildfire through some of the Facebook groups and I started to get messages and emails daily from people asking how they could order the product.

Want to learn more About MegasporeBiotics? Get More Info Here

I called Joe (co-founder of Rebel Health Tribe) and told him that we absolutely had to have Kiran on as a guest expert interview for our Primal90 Program to discuss all things microbiome, gut health, and spores. Kiran agreed, and his interview aired near the end of our month-long free launch event. Our inbox exploded. We had dozens of requests for Megaspore, and for ‘more Kiran’.

To satisfy both demands:

  • We worked out an arrangement with Physicians Exclusive which enabled us to allow our clients and members to order the product (it’s a practitioner-only product) via our account, so long as we provide them with instructions, education, and support regarding safe and optimal use of the product.  Megaspore is now available to all of our premium Primal90 Members, private coaching clients, as well as all of our Free Members.
  • Kiran agreed to be our featured guest on monthly Microbiome Series webinars, of which there has now been 6 episodes. These have become immensely popular, and we now have thousands of people, including dozens of practitioners, doctors, etc… who regularly tune in.

So that brings us to present-day. We’ve connected close to 1,000 people with Megaspore since March of 2015, and have received literally hundreds of messages, emails, phone calls, and text messages from people who have seen positive results using the product. We also now support approximately 70 doctors and other practitioners in the optimal use of the product in their practice – joining the over 2,000 practitioners using Megaspore in their practices world-wide.  (Want to share with your practitioner? Email us at [email protected]. We have practitioner-specific information to share.)

These tiny little spore-forming dynamos have totally transformed my practice, our business, and the inner ecology of thousands of people!

So… you’ve probably got about a dozen (or more) questions at this point. Let’s try to answer some of them.

The Human Microbiome Project – What does the current research regarding the microbiome say, and why is this important?

A massive project, costing millions of dollars, has been undertaken to better understand the human microbiome.  What they have discovered is changing the way that researchers and functional health practitioners are looking at disease and HMPoptimizing health. Here are a few facts coming out of the HMP that are particularly interesting:

  • There are approximately 10 trillion bacteria in (and on) our bodies vs. only 1 trillion human cells.  That’s right.  We have 10x more bacterial cells than we do human cells.
  • There are over 1,000 species of bacteria found inside our GI tract.
  • Bacterial genes outnumber human genes 150:1.
  • Our cells use bacterial DNA.
  • No two people have the same microbiome, not even identical twins.
  • There are over 1,000 different proteins made by bacteria in the gut which are essential to optimal body function
  • Several diseases are directly associated with a disruption to the microbiome.  These include, but are not limited to: Crohn’s, IBS, Asthma, Allergies, and Obesity.
  • Pathogenic bacteria/organisms (candida, h.pylori, etc…) are natural inhabitants of our gut, and are not problems in optimal conditions.  Eradicating them entirely has consequences we’re just beginning to understand.

How is Our Microbiome Populated?

So how do these bacteria get there? How is our gut populated? What disrupts this population? All good questions. (And all are answered in-depth in Episodes 4 & 6 of the Microbiome Series webinars) Let’s cover some basics:

  • During vaginal childbirth, we are exposed to our mother’s microbiome.  This occurs via the birth canal, and exposure to feces during the birth process.
  • We receive between 400-600 different species via breast milk.  Also, breast milk contains a powerful prebiotic (feeds good bacteria) which helps these strains to proliferate and colonize inside our GI tract.
  • Skin-to-skin contact with mom and dad provides some of the strains comprising a healthy microbiome
  • An infant’s microbiome reflects the mother’s vaginal bacteria for a few months, and then begins to resemble the mother’s mouth, skin, and gut after that.
  • After the very early stages of life, the microbiome is generally populated via environmental and food exposure.
  • Those who grow up in/live in a rural environment generally have much greater microbiome diversity/health than those who grow up in/live in urban environments.
  • After approximately 2 ½ years, the microbiome resembles that of adults.
  • Diversity is more important than overall population of certain strains.  A diverse microbiome will perform more functions, provide more benefits, and be more resistant to invasion, infection, and/or overgrowths.

So what can we learn from this information?

  • C-Section births and formula (vs. breastmilk) can have a very real impact on the diversity and overall population of a child’s microbiome.
  • Anti-biotic use, especially at a young age, can have an incredibly destructive effect on long-term health of the GI microbiome… and in turn, the health of that child/person.
  • Hand sanitizers, anti-bbacteriaacterial soap, and overall germ-phobia can have a very real, and significant detrimental effect on the development of healthy GI flora – especially related to diversity.
  • Our microbiome environment is largely determined by the time we are 3 years-old.

What Affects the Microbiome After Infancy? Why are we all messed up?

We just covered how the gut is initially inoculated/populated with our unique flora. Unfortunately (for many), that’s not the end of the story. Our modern life/society is definitely not conducive to the cultivation of a healthy microbiome. Here are some of the main culprits in regards to the destruction of our GI ecology:

  • Age –  Our microbiome population and diversity gradually decline with age.
  • Physiology – Factors such as surgery (anesthetics), and activity levels can have a major impact on the microbiome.
  • Diet – The quality of our diet can have a significant (positive or negative) impact on our microbiome.
  • Antibiotics (Especially during childhood) – Literally meaning “against life”, the overuse of antibiotics in today’s medical system is catastrophic when it comes to the health of our microbiome.  (Not to mention the extremely dangerous situation of antibiotic-resistant bacteria that we are creating.)
  • Genetics – There is a very loose correlation here, but worth mentioning.
  • Chemicals/Toxicity – We are exposed to thousands of chemicals, metals, etc… on a daily basis.  Many of these, such as chlorine (in tap water), and artificial sweeteners (junk food, soft drinks, etc…) are a couple examples of this.
  • Alcohol, Tobacco, Pharmaceutical Drug – Sorry, friends. Booze, smokes, and drugs are not friends of your microbiome.

Probiotic Supplementation – And Why I Wasn’t Crazy for Thinking They Didn’t Work

Sales of probiotics have eclipsed $800mil annually, according to many estimates.  There are dozens, probably hundreds, of different products on the market.  As already mentioned, I’ve actually tried or utilized at least 20 different brands, products, strains, etc… myself, and with clients over the last 8 years.  I’ve seen a few success stories, but overall – results from probiotic supplementation, especially if done without other supports such as digestive enzymes, Betaine HCL, anti-microbials to fight infections/overgrowths, etc… have been lukewarm at best.

The common approach/line of thought, when it comes to probiotic supplementation, is to “re-seed” with high doses of specific bacterial strains that we have found in certain areas of the digestive system. Unfortunately, I’ve learned this approach just simply doesn’t work.

When assessing a probiotic supplement, it’s best to ask four questions:

1)      What is the survival rate of this product/strain?  In order to have any benefit, a probiotic must be able to reach the desired location within your GI tract, while still alive.  Many strains of bacteria included in probiotic supplements today are very fragile, even requiring refrigeration.  The human gut, on the other hand, is over 96 degrees, involves very low pH (extremely acidic) environments, and is actually designed to keep out invading microbes.

Possibly the largest study done on the subject was done by the Food Standards Agency (FSA), along with Reading University, in the UK.  They tested 35 popular commercial probiotic products, mostly comprised of lactobacillus and bifidobacterium strains.  Here’s what they found:

  • At pH 1 (optimal stomach acid) – none survived with any viability.
  • At pH 2-3 (weaker stomach acid production) – 18 of 35 showed 50% survival.  So half of the bacteria, in StomachAcidhalf of the products, survived.
  • Those 18 were then put through a test to mimic the environment in the small intestine, involving bile salt tolerance.  Of those 18, only 6 showed survivability – and a chance to actually make it to the large intestine.
  • Those 6 were put through survival tests to determine survivability in the large intestine, and only 4 showed any survivability.

So, at the end of the day, only 4 of the 35 strains showed any chance of survivability, and even that was at, or around 50%.  These are not very good odds of survival.  Another study looked at two popular yogurts (Chobani®, Dannon®), and a leading commercial probiotic (Ultimate Flora Critical Care ®) and found that the bacteria within those products had a survival rate (pH 1.3 for 2 hours) of less than 1%.

All-in-all, this does not say much for the survivability of most probiotic supplements.

2)      What is the fitness of this particular strain?  Many common probiotics are actually aerobic (using oxygen) bacteria attempting to seed in an anaerobic (no oxygen) environment.  This is akin to trying to plant a bunch of fish in the desert.

Also to consider: can this strain(s) avoid immune destruction? Are there binding sites available for this strain(s)?  Bacteria viewed as invaders will be attacked, and find it difficult to adhere to the intestinal lining.

In fact, a study done in 2007 tested the adhesion ability of 11 strains of lactobacillus and found that the best of the bunch had an adhesion rate of 38%, followed by 24%, and then down from there.  This was using an intestinal cell lining model – giving the bacterial a completely optimal environment… unlike most people’s actual gut lining.

Not a very good showing in regards to the overall fitness of most probiotic products and common strains being used.

3)      Is it Natural?  Good questions to ask here would be: Are these strains found in nature?  Did the strains in these products co-evolve with each other, and with humans?  Do they belong in the human microbiome?

Also to keep in mind is that diversity is more important than sheer volume/numbers.  Overloading a few specific strains does not help with diversity… and diversity is the goal!   I’ve actually seen people create symptomatic imbalances in their microbiome by taking high doses of the same few stains over an extended period of time, or by over-doing it with the same fermented food in high doses, daily, for extended periods of time.

More (volume) is not always better.

4)      What is the quality of the product?  There have been a few studies and investigations into the actual quality of probiotic products, in general, and what has been found is rather alarming.  The European Union, when looking into the issue, found that many products contained strains different than were labeled (some were pathogenic), contained the wrong number of bacteria, contained mostly dead bacteria, and several other disturbing misrepresentations and indicators of poor quality control.

Do you really know what you’re getting?  More often than not, no… you don’t.

In summary, when we look at this “reseeding” approach through the lens of survival, fitness, nature, and quality, it doesn’t really seem like a very effective approach.

Introducing Spores! (Let’s get to the good stuff already!)

Spore-form bacteria are robust organisms that can survive the harsh environment of the stomach 100% intact. Through the evolutionary process, nature designed them to be transferred from human-to-human via the environment and food. They have evolved to be very stable in the environment and also to colonize the GI tract very effectively. In fact, studies have shown that certain developments of the human immune system specifically require spores.

What do we know about spores?

  • They are found all over the environment (soil, vegetation, dust, rocks, aqua-environments, digestive systems of insects, marine life, mammals, etc.) which means as a probiotic they are evolutionarily supported – a true probiotic.
  • Spores remain dormant until they get to the intestinal tract and then they colonize the bowel.  They pass through the stomach and upper GI with 100% survivability.
  • They are universally found in the human microbiome. They are normal organisms of our digestive tract.
  • There is a LONG history of use in industries where efficacy is closely measured, for example the pharmaceutical and agriculture industries.
  • Human studies have proven spores to be extremely safe and efficient.

MegaSporeBiotic

I realize, at this point, you probably feel like you’re reading a commercial, thinking to yourself “ugh… here comes the pitch”.  Trust me, I feel like I’m writing one.  I have, in fact, never written an article regarding a specific product in my MegaSporeentire career.  That is how strongly I feel about this subject, and how confident I am in the information being provided.

The Facts on MegaSpore Biotic:

  • It was developed under the advisement of spore expert Dr. Simon Cutting, Ph.D., by a practitioner for exclusive distribution by medical practitioners.
  • It utilizes verified, branded and registered strains – the only way to ensure proper characterization. Guaranteed prescription-grade and licensed from Royal Holloway at London University.
  • It is the only nutritional supplement probiotic on the market that contains Bacillus Clausii – a strain tested for more than 50 years, and is the best-selling probiotic prescription product in the world.
  • It contains five bacillus spore probiotics– the value of each strain is substantiated by a history of use and published science.
  • All strains are produced in a GMP facility under drug manufacturing guidelines.
  • It is the single-most, powerful spore probiotic formulation, and it delivers more than four billion live probiotic cells daily – a dose that matches and exceeds all prescription products of the same strains.  This goes a lot further than 100bil live probiotic cells of typical strains, which will mostly die-off in the process of getting to their target.
  • It is blended with a pre-biotic to enhance GI tract colonization
  • Its 100% spore format guarantees maximum survivability (100% survivability) and precise dosing
  • It is the most broad-spectrum probiotic. The clinically studied strains used in the formulation offer more than 35 indications for use in practice.
  • It is the FIRST probiotic formulation to deliver powerful, highly-bioavailable carotenoids via in-vivo production. Bacillus indicus is a patented, carotenoid rich strain.

Potential Benefits of Megaspore

  • Produce powerful antibiotics to protect against unwanted pathogenic bacteria
  • Provide pre-biotic and healthy conditions for the proliferation of beneficial flora, increasing the population and diversity of beneficial GI microbes
  • One gut model study demonstrated a 30% shift (towards more abundant/diverse beneficial flora) in microbiome in only 6 weeks of MegaSpore
  • Up to a 40% increase in Short Chain Fatty Acids (SCFA) production.  SCFA’s are known to increase colonic blood flow, improve fat metabolism, lower cholesterol and triglyceride levels, and reduce gut/systemic inflammation.
  • Help to develop GALT (Gut-Associated Lymphatic Tissue), an essential aspect of our GI immunity and integrity of the GI lining itself.
  • Increase T & B Lymphocytes (# and effectiveness), which are critical to optimal immune function
  • Shift from a state of Th2 dominance (allergies, asthma, inflammation) to more of a Th2/Th1 (adaptive immune response) balance
  • Improved pattern recognition, which can help with autoimmune conditions – lessens the instances of your immune cells attacking your own tissues by mistake
  • Has a big impact on most forms of GI dysbiosis (wrong bugs in the gut)
  • Produce digestive enzymes, specifically protease, which aids in the digestion and absorption of dietary proteins – the building blocks of life
  • Direct digestion of resistant starches with our contributor, Mike Kuhn, wrote about HERE, leads to reduced intestinal inflammation
  • Possible relief from microbiome-related diseases and conditions, such as IBS & Crohn’s
  • Produce powerful proteolytic enzyme, nattokinase
  • Beneficial when trying to heal “leaky gut” / eliminate GI permeability
  • Produce beneficial B-Vitamins, Vitamin K2, Quinols, Carotenoids, Asaxanthin, Lycopene, and Lutein. (Essential vitamins and very bio-available, powerful anti-oxidants)

In SummaryWhat to make of this information?

Personally, I’ve never seen any single supplement, product, etc… of any kind have anywhere close to the incredible impact we’ve seen Megaspore have with hundreds of people over the last 9 months or so. If you’d have told me a couple years ago that I’d see what we’ve seen, I wouldn’t believe you. That being said… why the big difference?

If some of the science above went over your head a little bit, that’s okay. Here’s my most basic understanding of the situation:

  • The idea that we can ‘re-seed’ or ‘re-populate’ our gut just isn’t backed up by much evidence or research.
  • I saw very little positive results when using the ‘best’ conventional probiotics on the market in my practice. This is likely because most do not survive the gastric environment, actually colonize the gut, or produce any real beneficial effects. Some popular strains in conventional probiotics can actually create more problems for people, especially those with histamine issues or Small Intestine Bacteria Overgrowth (SIBO).
  • Nowhere in nature, after infancy, would we encounter billions of lactobacillus or bifidobacterium, or any other strains used in conventional probiotics – they are inoculated via birth, breastmilk, contact with mother, and a little from the environment.
  • These bacillus spore-forming organisms are found in nature – in the air, water, soil – our natural environment. We would be exposed to them regularly if we lived in our natural environment. (Which we don’t – very far from.)
  • We evolved with these organisms, and they play several very important roles in our GI health/function – including, but not limited to: reducing inflammation, combating unwanted organisms, producing essential nutrients and enzymes, regulating our immune system, and creating an environment which is more hospitable to the friendly organisms which are beneficial to our health and more difficult for pathogenic (harmful) organisms to survive.

Next Steps – Where to go from here?

The FIRST thing is to sign up to see our popular Microbiome Series.  You’ll also be given access to more information on MegasporeBiotic including how to order.

If you have any questions, feel free to comment below!