Systemic Enzymes 101

More Posts from
Foundations & Optimization

RHT Health Foundations &

Optimization Guide

Our Top Recommendations in One Simple Guide -
Your Starting Point for Optimal Health!

Proteolytic enzymes have been used by functional health practitioners for decades to help people with a wide range of symptoms and conditions. While they’ve regularly been used for decades in the rehab, recovery, and pain management worlds – the use of systemic enzymes is now becoming commonplace in the functional medicine industry as well. Before we get ahead of ourselves, we should probably start with a few simple basic questions:

What are Enzymes?

By definition, and enzyme is “a substance produced by a living organism that acts as a catalyst to bring about a specific biochemical reaction.” Plants produce enzymes, animals (and humans) produce enzymes. All living things produce and rely on enzymes for function and survival. They are the catalysts, regulators, and triggers of countless biochemical functions, and even have powerful functions and roles of their own. There are thousands of enzymes – so we’re not going to discuss them all here, but we will review information pertaining to some of the most powerful, well-researched, and most commonly-used.

Potential Benefits of Systemic Enzyme Supplementation

  • Reduction in joint pain, arthritis-related symptoms, and systemic inflammation
  • Reduction in all forms of chronic aches and pains, including fibromyalgia
  • Improved recovery from exercise/training and faster/more complete healing from injuries & surgeries
  • Reductions in adhesions and scar tissue
  • Improved circulation and cardiovascular health – helping with conditions such as varicose veins, edema, and clotting-related conditions
  • Can be helpful with certain types of fibroids and cysts
  • Powerful antioxidant (Superoxide Dismutase found in Fibrenza) – which is protective against oxidative damage
  • Improved immune function & breakdown of foreign proteins in the blood
  • Reduced allergies, asthma, and food sensitivities
  • Improved cognitive function and overall brain health – preventative against certain brain-related conditions such as dementia

Get to Know Your Enzymes

Enzymes are very versatile. A single enzyme can have dozens (if not hundreds) of functions and roles. Therefore, there is a lot of crossover in regards to which enzymes do what. Also, enzymes can be used to aid digestion (digestive enzymes), or as a boost to systemic/whole body health (systemic or proteolytic enzymes). Some enzymes can function in either regard. If taken with food, they aid/improve digestion/absorption. If taken on an empty stomach, they’ll end up in the blood stream and perform various functions throughout the body.  To try and ease some confusion, and help you make education choices when it comes to enzymes, let’s identify and briefly discuss some of the most commonly-used and beneficial enzymes. The Supporting Actors – These are commonly used digestive and systemic enzymes which have been shown to be widely beneficial. They are common ingredients in most blended enzyme products:

  • Protease – General term which applies to, and encompasses any enzymes that break down/digest proteins – A variety of proteases are important/necessary to fully break proteins down into amino acids

Before we go further, perhaps you’re not too knowledgeable on proteins and amino acids. This will make more sense if you understand that proteins are merely chains of amino acids. Picture Legos. You can have all different colors, shapes, and sizes of Legos – just like there are different amino acids. Protease enzymes break apart proteins, or strings of amino acids, into the building blocks, or smaller groups of amino acids or even down to individual amino acids. Make a little more sense? Ok, let’s get back to it.

  • Bromelain – Found predominantly in pineapple core – Very well-researched and used as a medicinal food in Hawaii for allergies and recovery/injuries – Commonly used as a meat tenderizer – As a systemic enzyme, has been shown to be anti-inflammatory and can possibly modulate the immune system – Also functions as a digestive enzyme when taken with food
  • Pancreatin – General term that applies to a few different enzymes produced by the pancreas – Released directly into GI tract – breaks down food – Production drops after 25(ish) years of age, becomes a stress on the pancreas to maintain necessary levels – Links between low pancreatin production and low insulin production, damage to cells in pancreas which produce insulin (Anyone with pancreas-related health issues will generally see low pancreatin production/output)
  • Trypsin – Like pancreatin, also made by the pancreas – Released in inactive form, activated by stomach acid (need adequate HCL production!) – As a digestive enzyme, breaks down/digests proteins – Shown to be effective systemically for osteoarthritis and reducing joint inflammation/pain – In Asia, there is a trypsin paste that is used on wounds to speed healing and break down scar tissue (may reduce scarring) – As pancreatic function drops, production drops (age, diabetes, etc…)
  • Peptidase – General term referring to several peptidase enzymes, all of which are proteases – Responsible for further breaking down mid-sized, or partially broken down proteins and breaking them into smaller segments (called peptides) – Breaks down proteins that trigger allergic responses and food sensitivities – Used as digestive and systemic enzyme
  • Amylase – The only type of enzyme found in saliva – Breaks down amylose, which is found in carbohydrates (rice, grains, veggies, potatoes, etc…) – Also produced in small intestine – helps with carbohydrate breakdown
  • Papain – Found predominantly in papaya – Like bromelain, also tenderizes meat and aids in digestion/breakdown of dietary protein – Can work very well for pain & inflammation when combined with bromelain – Used as digestive and systemic enzyme
  • Lipase – General term for enzymes that breakdown fat – The body makes many lipase enzymes, each breaks down different fats – Undigested fat in the GI tract contributes to microbiome disturbance, and motility issues – Show to help with acid reflux, and beneficial for those who have trouble digesting fat (or missing a gall bladder)

The Stars of the Show – These are the most powerful systemic enzymes available, with the most impressive research and potential benefits. They are always to be taken away from food, otherwise they’ll just become (expensive) digestive enzymes!

  • Superoxide Dismutase (SOD) – Cells in our body produce SOD to break down superoxides, which are corrosive and cause free-radical damage (think rust, or aging) – Shown to help reduce inflammation and joint damage, and speed/enhance recovery from injury or surgery – Superoxides are byproducts of respiration/breathing, and are elevated by smoking, drinking, intense training, and/or having high toxic exposure
  • Seaprose – VERY powerful protease enzyme (breaks down proteins) – In purest form, is strong enough to rub off your fingerprints! (Note to bank robbers!) – Is a powerful expectorant, meaning it breaks down and gets rid of mucus build-up – Has very strong anti-inflammatory benefits – Used as a prescription drug in Japan to treat inflammation and joint pain – Can break up uric acid (may help with conditions like Gout) – Shown to increase immune function, helping to fight off infections and overgrowth
  • Nattokinase – Produced by bacillus subtilis (the same strain in Megaspore) found in the fermented food, Natto – First discovered by Japanese Samurai who noticed it increased strength and endurance – Natto is prescribed in Japan for high blood pressure, dementia, high viscosity blood, and high coagulation conditions – Has been shown to lower high blood pressure, reduce excess fibrin in the blood (makes blood thick, prone to clotting), improves circulation, and also for brain health – Has shown positive results in regards to vericose veins, edema, DVT’s, and prevention of various brain-related conditions. – May actually turn you into a Samurai (See video for more details on this possibility)
  • Serrapeptase – Can be produced by bacteria in the human GI tract – Made by silk worms, with the function of breaking down their cocoon – Prescribed in Japan for anti-inflammatory and anti-edemic properties – Shown to improve circulation and also may have analgesic (pain reducing) properties

Check out the video below where Kiran Krishnan helps us breakdown each and every one of these enzymes.

Don’t Our Bodies Produce Enough?

The answer to this isn’t exactly straight-forward. Yes and no. When we’re young, our production of enzymes is high, and we have solid stores of enzymes. As we see with many other health markers, our production of enzymes, and therefore our stores of enzymes, decrease as we age. Somewhere around 30 years of age, our enzyme production and stores start to drop. In addition, many of the systemic enzymes that have been discovered to have health benefits aren’t made in the human body – so we don’t produce those at all. As production and stores of enzymes drop, we see increased fibrin build-up (atherosclerosis), increased impurities in the blood/cardiovascular system, increased systemic inflammation, fatigue, reduced/impaired digestive capabilities, and many other symptoms. Of course, these issues are multi-faceted, and not completely dependent on enzymes – but it’s very clear that diminished availability of enzymes absolutely plays a role.

Inflammation, oxidative stress, poor diet, and toxicity can all reduce our enzyme stores/availability as well. By the time we pass 50 or 60 years of age, our enzyme production and stores are greatly diminished – along with bone density, muscle mass, cognitive function, and dozens of other functions and health markers. That is precisely why so many functional health practitioners are now using and recommending supplemental systemic enzymes! Before we get into the potential benefits of doing so, I’d like to cover a couple difficulties with systemic enzyme supplementation.

Challenges with Systemic Enzyme Supplementation

Before we get into all the potential benefits of supplementing with systemic enzymes, I’d like to break down a few of the challenges and difficulties:

  1. Dosing of systemic enzymes generally has to be extremely high, and frequent. For example, the past 3 years, I’ve taken the most popular systemic enzyme product on the market. In order to really notice the effects of reduced muscle soreness, increased recovery, absence of chronic shoulder pain, etc… I need to take at least 5 tablets 3-4x/day, or 15-20 total tablets per day. This is very inconvenient, to say the least.
  2. Even the best combo products (containing many systemic enzymes) I’ve ever found, or know to exist on the market (until very recently), are missing a number of the “Superstars” listed above. Therefore, I’ve been supplementing with the popular combo product and also taking separate Serrapeptase and Nattokinase on the side. More doses, more bottles, more money.
  3. Many systemic enzyme products consist of either animal-based enzymes or plant-based enzymes, but rarely combine the two in any significant manner. Some people do better with one type, others with the other – and this can be confusing, frustrating, and lead to wasting time and money on products that won’t work well for you.
  4. Systemic Enzyme products are very expensive. Considering I’ve been buying 3 different products for myself, I’ve easily been spending $100/month (probably more) on enzyme supplements. While I feel they’re worth that investment, and the benefits outweigh the cost, this high price is prohibitive for a lot of people who could really benefit from them.

Despite all of these challenges and shortcomings, systemic enzymes are something I’ve personally been using and recommending in my practice for over 4 years. If I’m asked to name off my “top 3 supplements” or “a few supplements I won’t go without” – they always make the cut. That’s why I was so excited when it was brought to my attention (by Microbiologist Kiran Krishnan, who has no affiliation with the company) that there is a new systemic enzyme product on the market which solves all four of these problems, and contains EVERY SINGLE ONE of the enzymes listed above!

Introducing Fibrenza The Most Complete Systemic Enzyme Product on the Market

During one of our recent episodes of The Microbiome Series, our extremely popular webinar series – I mentioned that it “would be great if there were a systemic enzyme product that contained all of the enzymes in the most popular combo products, as well as Nattokinase and Serrapeptase so that I don’t have to buy and use three separate products!”

Kiran Krishnan, our Microbiologist guest expert for that series, proceeded to tell me about a product called Fibrenza that he had recently come across at one of the medical conferences he speaks at almost every weekend. He told me (and our entire audience) that it did contain everything FIBRENZAI was looking for, and then some!

Immediately following the webinar, I jumped on the Internet looking for information. I found their website, and to my amazement – it contained everything I was looking for, in addition to Seaprose and SOD, both of which I’d never even seen in any enzyme product previously!

After hearing Kiran on our show, several of our audience members went ahead and ordered the product. To say that reports back have been positive would be an understatement! We are VERY excited to be able to make this product available to our Free and Premium Members – and can’t wait to hear about the results!

Our inbox is constantly flooded with products that people want us to check out, promote, share with our audience, etc… We can proudly say that this is only the third product in over a year that we’ve felt strongly enough about to put our full endorsement and name behind. (Along with MegasporeBiotic & MegaQuinone)

Why Fibrenza?

  • Fibrenza contains the widest specturm of proven, researched systemic enzymes of any product on the market.
  • Fibrenza is the only product on the market that has taken the most potent available forms of animal and plant-based enzymes and combined them.
  • Fibrenza is the only product on the market that contains Seaprose, an extremely powerful systemic enzyme.
  • Due to the powerful nature of Fibrenza, it requires fewer doses, and smaller doses than the most popular systemic enzyme products to see faster and potentially superior results.
  • Fibrenza can replace several products – making it far more convenient and budget friendly. I’m personally spending less than half of what I was spending on my trio of products previously.
  • Fibrenza is an advanced blend of 14 powerful systemic enzymes that are specifically formulated to supplement the bodies’ ability to dissolve fibrin, cleanse the blood, detoxify the body, and maintain a healthy inflammation response. These functions are the cornerstones of many anti-aging regimens.

We’re offering Fibrenza for pre-sale at a discounted price (In fact, we can’t even mention the price publicly). If you’re a Free Member or Premium Member, you now have exclusive access in your Dashboard. We’ll be taking limited orders over the next few days. Once our initial round of orders are complete, it will likely be another month before we offer it again. Be sure to place your order now. Join Now as a Free or Premium Member or Go to your Dashboard to Learn More

*The statements made herein have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.  ]]>

RHT Health Foundations &

Optimization Guide

Our Top Recommendations in One Simple Guide -
Your Starting Point for Optimal Health!

Foundations & Optimization Products

Get Social

Recent Podcasts

Recent Courses

Brain & Nervous System Masterclass

Brain & Nervous System Masterclass

16 Leading Experts Share Cutting-Edge Science, Effective Practices, and Clinical Strategies to Optimize Brain & Nervous System Health in Kids and Adults

Wellness Optimization Series

Wellness Optimization Series

Learn about the immune system and what you can do to optimize wellness. This series provides valuable information on how an individual can be proactive during a time of crisis

AutoImmune Masterclass

2 Masterclass Bundle

Learn all about Autoimmune Diseases with 17 of the worlds leading experts and Optimize Your Microbiome To Radically Improve Your Health And Well Being!

AutoImmune Masterclass

Autoimmune Masterclass

Autoimmune Masterclass brings together 17 of the world’s leading doctors, researchers, and experts on autoimmune diseases who each present their own mini-class on autoimmunity.

Get the RHT Newsletter

Be the first to get access to special offers, new podcasts, courses, products and events from Rebel Health Tribe. 


MegaSporeBiotic is a probiotic blend of 5 Bacillus spores that have been shown to maintain healthy gut barrier and immune function. 



  1. Michael, Thank you for mentioning the Fibrenza. Looks like the ticket in one product. A question for Kiran, is the serprose-s in Fibrenza a synthetic version of the enzyme seaprose, or as effective?

    • Hey Trish! I was pretty excited to find this blend, as I was previously taking 3 products to get everything I wanted! I sent you an email cc’d with Michael from the company who makes Fibrenza. Kiran doesn’t have anything to do with this one… just wanted to lend his expertise for an interview!

Leave a Reply

Your email address will not be published. Required fields are marked *

Post comment