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Probiotics are the fastest growing category in the supplement industry. Recent research done by the NIH has defined probiotics by strict criteria:
2 Years, the expiration date will be indicated on the box.
None have been reported.
What about if on an empty stomach? Yes. The amino acids and carbohydrates in food help the spores move from their dormant (spore state) to their active (vegetative state) form in the GI. There are tremendous immune benefits if the spores are made to germinate into their vegetative state in the upper GI itself and so taking just after a meal (10-20 mins after) is ideal.