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Connection Between an Unhealthy Microbiome and Autoimmune Disease


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Webinar Transcript

Kiran Krishnan:
When your innate immune system responds to the presence of a pathogen… Remember, I gave you the
analogy that it’s like a blow torch response to dealing with mosquitoes. Right? You’re going to kill the
mosquitoes where you’re also burning and damaging the wall behind it. So when the innate system
responds, it’s nonspecific. Meaning it’s not responding to just one particular virus or one particular
bacteria, it’s responding to a region where there’s a problem. And so it just comes in carpet bombs at
region, which means that your own cells are also going to get damaged in the process.

Right. Now, one of the really important aspects of immune clearing, is that your own cells have to be
repaired, and all of your own cellular debris have to be cleaned up. And there are cells that do that.
There are cells that clean up all of that damage, but they have to be activated by activating G protein
couple receptors by stimulating interleukin 22. And all of those signals come from your microbiome.

Now, what happens if you don’t fix the damage? Well, if you don’t fix the damage, then all of your own
cellular debris can get caught up and accidentally presented to the adaptive immune system as part of
the problem. Right? Your macrophage or your dendritic cell may accidentally your own tissue proteins or
your own tissue structures and present it to your T cells and B cells as the problematic or invading
species. And then now you start developing autoimmune conditions. Right? That’s how an infection can
lead to autoimmunity.

That’s what we’re seeing in this pandemic virus is as well. People with long haul syndrome are seeing an
autoimmune induction of their neurological system, their muscular system, and so on because there
was so much inflammatory damage. And those individuals did not have a good, effective, clear repair
and antiinflammatory mechanism. And so their macrophages and dendritic cells accidentally presented
their own neurological tissue samples to the B cells and T cells. And then they started developing
antibodies and memory T cells against their own tissue. Right? That’s called a bystander effect. Where
your own tissue becomes an accidental bystander in the war, in the damage, and then accidentally
becomes a target.

So in order for that to not occur, you need a healthy microbiome producing the antiinflammatory
signaling, producing the butyrate to activate the G proteincouple receptors on cell surfaces and
stimulating interleukin 22 to repair the damage that’s going on. That has to be happening as the
infection is coming under control and as the immune system is progressing along towards the adaptive.

We cannot overstate the importance of a healthy microbiome in that whole kinetic aspect of how the
immune system functions. If you don’t have a healthy microbiome, you have a huge risk of going down
the road of a cytokine storm and going down the road of auto activation, and then ending up with an
autoimmune type of condition as a result of that infection.

Kiran Krishnan

About our Guest

Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 17 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. He left University research to take a position as the U.S. Business Development and Product Development lead for Amano Enzyme, USA. Amano is one of the world’s largest suppliers of therapeutic enzymes used in the dietary supplement and pharmaceutical industries in North America. Kiran also established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition.

Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development, research and marketing company in the U.S. Dietary Supplement and Medical Food markets. Most recently, Kiran is acting as the Chief Scientific Officer at Physician’s Exclusive, LLC. and Microbiome Labs. He has developed over 50 private label nutritional products for small to large brands in the global market. He is a frequent lecturer on the Human Microbiome at Medical and Nutrition Conferences. He conducts the popular monthly Microbiome Series Webinars through the Rebel Health Tribe Group practitioner training program, is an expert guest on National Radio and Satellite radio and has been a guest speaker on several Health Summits as a microbiome expert. He is currently involved in 9 novel human clinical trials on probiotics and the human microbiome.

Kiran is also on the Scientific Advisory Board for 5 other companies in the industry. Kiran offers his extensive knowledge and practical application of the latest science on the human microbiome as it relates to health and wellness.

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