And so here is a problem that we end up in modern society. The language used by the microbiome to communicate with immune system early on, when it first detects the presence of an infectious agent are all these types of cytokines. Interferons and cytokines, interleukins, interferons and so on. All of these messengers are inflammatory messengers. And the way your body’s supposed to work when it’s healthy is you’re supposed to have low levels of inflammation throughout your body. And so that if all of a sudden there’s an inflammation flare in some part of your body, it quickly attracts your immune system to that side of action. That’s the signal that the local microbes use to recruit your immune cells to that site of action. These are the examples of the interferons and interleukins that are the inflammatory cytokines that the microbiome uses to recruit your immune cells.
The problem is in places like North America, in the Western world, at least 50% of adults have high levels of chronic illness and all of the chronic illnesses that we have, like diabetes, autoimmune disease, arthritis, cardiovascular disease and so on, are all hallmarked by having chronic inflammation, which means all of these signals are chronically elevated in these individuals. Here are individuals with predispositions like obesity, diabetes, hypertension, cardiovascular disease, renal disease, autoimmune conditions, pancreatitis, IBD, all of these conditions are hallmarked by having elevated chronic levels of all of these inflammatory markers. That creates a significant problem for how your immune system is supposed to respond.
That creates a significant issue of something called loss signaling, which I’ll talk about in a second. But the biggest driver of chronic inflammation in chronic illness in the Western world is leaky gut. The moment your gut becomes leaky, you got this translocation of LPS, lipopolysaccharide into circulation and when you get the translocation of this endotoxin that’s made by bacteria in your gut, when you get that translocation into circulation, it turns on all of those very same inflammatory markers systemically. It does it in local tissue but it also does it systemically and disruption so the gut microbiome can drive this kind of chronic inflammation.
About our Guest
Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 17 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. He left University research to take a position as the U.S. Business Development and Product Development lead for Amano Enzyme, USA. Amano is one of the world’s largest suppliers of therapeutic enzymes used in the dietary supplement and pharmaceutical industries in North America. Kiran also established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition.
Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development, research and marketing company in the U.S. Dietary Supplement and Medical Food markets. Most recently, Kiran is acting as the Chief Scientific Officer at Physician’s Exclusive, LLC. and Microbiome Labs. He has developed over 50 private label nutritional products for small to large brands in the global market. He is a frequent lecturer on the Human Microbiome at Medical and Nutrition Conferences. He conducts the popular monthly Microbiome Series Webinars through the Rebel Health Tribe Group practitioner training program, is an expert guest on National Radio and Satellite radio and has been a guest speaker on several Health Summits as a microbiome expert. He is currently involved in 9 novel human clinical trials on probiotics and the human microbiome.
Kiran is also on the Scientific Advisory Board for 5 other companies in the industry. Kiran offers his extensive knowledge and practical application of the latest science on the human microbiome as it relates to health and wellness.