Recent Videos

The 3 Strains Used in HoloImmune: Power of Postbiotics

The Role of Bile in SIBO and Upper GI Dysfunction

Stomach Acid Production, Microbes, and the Science of Antacids

Components of Healthy Gut

Webinar – 3 Secrets to Fix Your Brain That Your Doctors Don’t Know About

Webinar Transcript


Trypsin is the next one up. I don’t know anything about trypsin.


Well so trypsin, although the name doesn’t suggest it, is also made by the pancreas, and it’s actually released in an inactive form, and is actually hydrolyzed by stomach acid to some degree to the active form a trypsin. Trypsin is primarily, again, a digestive enzyme. It has a very specific role in breaking down large chains of protein to smaller chains of protein so that your body can actually start the breakdown process to release amino acids so you can utilize it. Trypsin plays a very important role in that. But trypsin also has been shown clinically to work well against things like osteoarthritis and reducing joint inflammation, so this systemic impact on trypsin as well, it can be absorbed into the circulatory system and seems to help with joint pain.

There are some places, and actually there may be a prescription drug that uses trypsin as a paste form to put it on wounds, because it helps with wound healing and actually breaks down some of the scar tissue formation and things like that to actually help with wound healing. I can’t remember where, I don’t think they sell it in the US, or it might be in Asia, or in Europe where they have the trypsin based wound healing creams, which are prescription products. And some people say it has some antimicrobial effects as well, sort of helps keep the would clean, but trypsin is an important enzyme. Again, as your pancreatic function drops as you age, you’re not producing as much trypsin as well, so it becomes certainly when in you’re in your 40s, 50s, 60s, it becomes quite important to look at a product that contains trypsin.


I never heard of the wound cream so that’s interesting.


Yeah it seems to help modulate with it. So there’s another thing, matrix metalloproteinases. So matrix metalloproteinases are abbreviated MMPs. Matrix metalloproteinases are types of proteinases that actually affect tissue remodeling, and nattokinase has been suspected of being able to affect MMP activity, same with trypsin and chymotrypsin. So we’ve had people report to us before when using trypsin, chymotrypsin or nattokinase that they see scars that they’ve had for a long time diminish to some degree, because that’s one of the roles of matrix metalloproteinases is to remodel the tissue so it reduces scar formation, and that may be part of the benefit of putting it on a would as well.


It’s fascinating how many … you think one enzyme, one function.


Yeah, you know they do so much and they’re all so specific in what they do.


It’s just crazy. The further we go down all these rabbit holes and things, the less I feel like I know. And it’s funny. It’s like running around in a cave with a flashlight.




And it’s here, looking at it right now, then you think, oh I’ve got this all figured out and you look up and there’s bats.



Kiran Krishnan, Microbiologist

About our Guest

Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 17 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. He left University research to take a position as the U.S. Business Development and Product Development lead for Amano Enzyme, USA. Amano is one of the world’s largest suppliers of therapeutic enzymes used in the dietary supplement and pharmaceutical industries in North America. Kiran also established a Clinical Research Organization where he designed and conducted dozens of human clinical trials in human nutrition.

Kiran is also a co-founder and partner in Nu Science Trading, LLC.; a nutritional technology development, research and marketing company in the U.S. Dietary Supplement and Medical Food markets. Most recently, Kiran is acting as the Chief Scientific Officer at Physician’s Exclusive, LLC. and Microbiome Labs. He has developed over 50 private label nutritional products for small to large brands in the global market. He is a frequent lecturer on the Human Microbiome at Medical and Nutrition Conferences. He conducts the popular monthly Microbiome Series Webinars through the Rebel Health Tribe Group practitioner training program, is an expert guest on National Radio and Satellite radio and has been a guest speaker on several Health Summits as a microbiome expert. He is currently involved in 9 novel human clinical trials on probiotics and the human microbiome.

Kiran is also on the Scientific Advisory Board for 5 other companies in the industry. Kiran offers his extensive knowledge and practical application of the latest science on the human microbiome as it relates to health and wellness.

Why Subscribe?

  • Save $$$ on your favorite products every time!
  • Refills arrive at your door, on time, every month.
  • Update/change subscriptions any time,
  • FREE SHIPPING in the US on order more than $75.
  • Check something off your "to-do" list forever!