MegaMucosa Background 

MegaMucosa TM is the first complete mucosal support supplement of its kind, formulated to REBUILD a healthy mucosal barrier. MegaMucosa TM also contains dairy-free immunoglobulins clinically shown to support a healthy immune response in the mucosa and a state-of-the-art flavobiotic clinically shown to support microbial diversity and alleviate barrier dysfunction, otherwise known as leaky gut. 

The mucosal system is a very important part of the human immune system. Not many people think of mucus as being protective, but it is the main interface between the human body and the outside world. The mucosal system contains 150 times more surface area than skin, which makes it one of the most important immune barriers. The health of the mucosa determines how the body interacts with antigens; therefore, the integrity of the intestinal mucosa can dictate overall immune function.1

Research suggests that the intestinal mucosal barrier plays a significant role in the pathogenesis of many chronic conditions, including inflammatory bowel diseases (IBD), depression, acquired immunodeficiency syndrome (AIDS), gastroesophageal reflux disease (GERD), acute pancreatitis, and more.2-6 Some researchers even believe that mucosal damage may be the initial injury that leads to many of these chronic conditions. Unfortunately, the Western lifestyle is quite damaging to the intestinal mucosa. Antibiotics, NSAIDs, stress, alcohol, gut infections, and other factors can easily degrade the intestinal mucosa, weakening the immune system and allowing unwanted toxins to enter circulation and trigger an inflammatory response.

MegaMucosa Ingredients

MegaMucosa TM contains four amino acids, MicrobiomeX ® bioflavonoids from citrus sinensis and citrus paradisi, and ImmunoLin® serum-derived bovine immunoglobulins. 

MegaMucosa Function

MegaMucosa TM is formulated to help the body rebuild its protective intestinal barriers. The mucosal layer that protects the intestinal lining consists of a thick, gel-like protein known as mucin2. In order to increase the synthesis of this protein, the body needs a plentiful supply of butyrate and four amino acids: L-proline, L-serine, L-cysteine, and L-threonine.

MicrobiomeX ® is a natural citrus extract rich in polyphenols that supports digestive health and immunity by increasing microbial diversity in the gut and improving gut barrier function. A clinical study using 500mg of citrus fruit extract found a 22% increase in butyrate production and a significant reduction in fecal calprotectin. Both results suggest that citrus polyphenols can reduce inflammation and modulate the microbial composition in the gut. 

Finally, the addition of the dairy-free immunoglobulins provides immune protection from the numerous toxins in the GI tract. Serum-derived immunoglobulins will enter the digestive tract and begin binding and neutralizing toxins in the gut before leaving the system through defecation. In this way, the immunoglobulins help to reduce the toxic load in the gut and buy time for the intestinal lining and mucosal barrier to repair themselves with the necessary building blocks. These IgG antibodies can reduce the damage of metabolic endotoxemia and neutralize LPS, an endotoxin that triggers mucosal inflammation. 

Together, these ingredients function to reduce the overall toxic load on the gut and rebuild a strong and healthy mucosal barrier. 

Research

Studies Supporting MegaMucosa TM

Study	# of Subjects	Variables Studied	Outcome
Amino acids
Faure M, et al. Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006; 136(6): 1558-64.	32 rats	Colonic mucin production	An amino acid cocktail containing L-threonine, L-serine, L-proline, and L-cysteine stimulated colonic mucin synthesis by 95%.
Citrus polyphenols
Randomized clinical study: Efficacy of MicrobiomeX on microbiome composition and gut inflammation in healthy and overweight adults. BioActor. 2017;1-22.	60 adults	Fecal SCFA and calprotectin	12 weeks of supplementation with MicrobiomeX significantly increases SCFA production and reduces fecal calprotectin levels
Romier B, Schneider YJ, Larondelle Y, During A. Dietary polyphenols can modulate the intestinal inflammatory response. Nutr Rev. 2009;67(7):363-78.	Review	Microbial diversity	Polyphenols can modulate gut microbiome structure and function to improve gut health
Serum-derived Immunoglobulins
Shaw AL, et al. Impact of serum-derived bovine immunoglobulin/protein isolate therapy on irritable bowel syndrome and inflammatory bowel disease: a survey of patient perspective. Patient Prefer Adherence. 2017; 11:1001–1007.	595 adults	Stool frequency	SBI decreases stool frequency in patients with IBS or IBD
Dlugosz A, et al. Increased serum levels of lipopolysaccharide and anti-flagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 2015: 27(12):1747-54	194 adults	Serum LPS, anti-flagellin IgG antibodies	Higher LPS and anti-flagellin antibodies were associated with IBS-D.
Wilson D, et al. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013; 6:49–60.	15 adults	GI symptom scores	SBI decreases abdominal pain, flatulence, bloating, urgency, loose stools, and duration of IBS-related symptoms
Asmuth DM, Ma ZM, Albanese A, et al. Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. AIDS. 2013; 27(14):2207–2217.	8 adults	CD4+ lymphocyte, stool consistency, and intestinal-fatty acid binding protein (I-FABP)	SBI significantly increases intestinal mucosal CD4+ lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in HIV enteropathy.
Detzel CJ, Horgan A, Henderson AL, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PLoS One. 2015; 10(4):e0120278.	Caco-2 cell line study	Antigen binding	SBI may reduce pro-inflammatory cytokine production via antigen binding

Indications

Celiac disease

Autoimmune disease

Cancer

Gut infections

Inflammatory Bowel Diseases

Irritable Bowel Syndrome

Advantages

MegaMucosa TM was formulated to REBUILD intestinal barriers. Rather than just follow the crowd with this formula, Microbiome Labs chose to innovate a comprehensive product based on research that could effectively rebuild the intestinal mucosa. Addressing the intestinal mucosa is key because a thick mucosal barrier is what ultimately protects the intestinal lining from toxins and pathogens. Rather than just focusing on rebuilding the intestinal lining, Microbiome Labs is focused on rebuilding from the ground up in order to provide a more reliable foundation. 

Many gut healing supplements are designed to soothe intestinal inflammation, but they often do very little to address the root cause of the inflammation. MegaMucosa TM, on the other hand, helps to quickly reduce the toxic load on the body while also rebuilding protective barriers. In this manner, MegaMucosa TM is more multi-functional and robust than other common gut healing supplements. Additionally, MegaMucosa TM uses serum-derived bovine immunoglobulins (SBI) rather than colostrum-derived immunoglobulins. See our previous post on Mega IgG2000 to learn more about the benefit of SBI.

Suggested Use

Take 1 scoop daily with or without food, or as directed by your healthcare practitioner. Mix into 16 oz of cold water or liquid of your choice. 

MegaMucosa TM is safe for children and safe to use while pregnant and nursing. 

Synergy

MegaMucosa TM works best when taken together with MegaSporeBiotic TM and MegaPreBiotic TM, as part of the Total Gut Restoration system. 

Duration

MegaMucosa TM can be taken indefinitely at the suggested dose of 1 scoop daily or at a maintenance dose of 1 scoop weekly. 

Contraindications

You should not take this product if you are vegan. Use with caution if you have an allergy to beef, as the immunoglobulins are derived from the serum of cows.

References

1. Citi S. Intestinal barriers protect against disease. Science. 2018;359(6380):1097-1098.
2. Michielan A, et al. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015; 2015:628157.
3. Maes M, et al. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008;29(1):117-24.
4. Paiardini M, et al. Mucosal immune dysfunction in AIDS pathogenesis. AIDS Rev. 2008;10(1):36-46.
5. Kandulski A, et al. Gastroesophageal reflux disease–from reflux episodes to mucosal inflammation. Nat Rev Gastroenterol Hepatol. 2011;9(1):15-22.
6. Liu H, et al. Early gut mucosal dysfunction in patients with acute pancreatitis. Pancreas. 2008;36(2):192-6. 
7. de Punder K, et al. Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability. Front Immunol. 2015;6:223.