Michael Roesslein:

So Steve, man, thanks for doing a webinar today. I tend to only ask you when you’re traveling, if you’re able to do live things on the internet, so I appreciate the flexibility with that. We are going to go through your line of products, which the reason I wanted to do this webinar is because since we started retailing your products and we did those webinars, we get a lot of questions, some from practitioners about how do I use these in my practice, or how can I get an account set up, or which one do I use for which people? Or questions that you’re far more qualified to answer than I am, so I figured we could ask them to you, and then we will have this as reference for all the professional types that want to use your product line in their practice. And then we open the doors to everybody because our audience loves to learn things and they generally ask as good of questions as the practitioners do. So we’re going to do a little deep dive into the three Healthy Gut products.

            Steve Wright is the founder of Healthy Gut, was co-founder of STD Lifestyle. He’s been involved in some way or another in the world of gut healing since I was a bartender, a long time ago. I think Steve, one of your interviews with Sean Croxton was probably maybe the first thing I ever saw in the world of functional health, nutrition, any of that. And I was like, “What are these guys talking about?” But that was that long ago. So I think I just dated both of us. If anybody here is familiar with Sean Croxton’s summits. So it was late 2000s, I think, maybe-ish. 2010, no?

Steven Wright:

Yeah, 2010, probably.

Michael Roesslein:

2010.

Steven Wright:

2010, something like that.

Michael Roesslein:

Yeah. Which feels like it was last week and it was 12 years ago. So been in the game a long time. Steve’s a voracious researcher. If he doesn’t know the answer to a question, he pretty much just doesn’t stop reading things about it until he figures it out. And the product line, which if you attended any of our webinars, we’ve done on all three of the products, the HoloZyme, the HCL Guard and the Tributyrin-X were pretty much created out of necessity because you wanted something to help you. And the products that were on the market in those categories didn’t work very well for various reasons. So we have individual ones that go in really deep dive on each of the three. Today. I’d like to just like give a little overview of what each one is, best practices, when to use it and then answer some Q&A, any contraindications if there are any, and basically a guide to practitioners or individuals who want to use these products to help their digestion. I think that’s everything.

            So we started with HoloZyme, with Rebel Health Tribe, and that was the first year products that I used. I don’t know, actually on your end, which one is the most popular or the most used, but digestive enzymes are something that a lot of people know. So I guess we could start with that. First off, where are you, are you in Dallas?

Steven Wright:

Yeah. I’m in Dallas in an ice storm right now.

Michael Roesslein:

There’s ice storms in Dallas?

Steven Wright:

Yeah. Today.

Michael Roesslein:

Oh. Today, because you were going to Dallas for a thing.

Steven Wright:

Right. Yeah, just for me. It was just a surprise for me.

Michael Roesslein:

Okay. I wasn’t sure if you left Dallas or were in Dallas. You had mentioned before we went on air. Steven’s in Dallas for a conference and they made an ice storm for him so he got to fly in early and so we get to have him in a hotel.

            So HoloZyme is a comprehensive digestive enzyme product that also has co-factors that make enzymes work.

Steven Wright:

Correct.

Michael Roesslein:

That’s my less educated than you are explanation of what it is. So maybe we just go in a little bit to the formula itself, what enzymes are in there, why those enzymes are in there, and then what the other ingredients are and kind of why the formula is what it is.

Steven Wright:

Yeah. Okay. Great. Well, I’m going to as we talked to you about, I’m going to sort of do this whole talk as if I’m talking to a practitioner and [crosstalk 00:06:08].

Michael Roesslein:

That’s fine.

Steven Wright:

And then if you’re not, that’s totally cool too. We welcome you as well. So when you’re trying to select a digestive enzyme for your clients, one thing you want to select for, or if you don’t select for it, if you just want to notice as you give it to people or prescribe it to people, is the difference in efficacy, basically how many people actually buy it on the second time you recommend it, or how many times people actually will getting mad if you try to take it off their health plans, things like that. And in the past, most of the other brands out there, I found only 30, 40% of people would actually defend keeping their enzyme product. And that was my experience as well. Is that I could take it one day and wouldn’t notice any, and then I take the next day, I noticed something. And so HoloZyme was built to combat that.

            There was multiple things that were put into place. One of those was the different types of enzymes. And so if you look at the back of the bottle, HoloZyme, there’s three classes of enzymes. And I put all three in there because there’s no way to test to know who’s deficient in which ones. I mean, there are a few tests, but you’d have to knock someone out and withdraw their intestinal juices, and spin them up, and figure that out and that’s just not feasible. And so class one would be pancreatic enzymes, and those are amylase, lipase and protease. Class two are brush border enzymes. And so those are enzymes like maltase, lactase, invertase. And then the other class, class three is microbiome enzymes. And these are enzymes that are actually secreted by the healthy microbiome. These are things like alpha-galactosidase, xylanase, and cellulase. So I should have brought the bottle. The bottle is way behind me, over there, and I’m a big dummy, so I didn’t bring it over to my desk here.

Michael Roesslein:

I got one downstairs. I can go get it if we need one.

Steven Wright:

No, no. I think I remembered most of them there. So one of the reasons why I think HoloZyme works so well is that we cover all three of those. So whether you are someone who actually has a pancreatic enzyme deficiency or not, we got that covered. Whether you’re someone who has damage to the small intestinal area, we got that covered. And then it seems for a lot of people with digestive issues, especially bloating and food sensitivities, those microbiome enzymes tend to be very helpful. And so that was some of the innovations we brought in as far as just the actual makeup.

            Then the other reason why a lot of other enzymes fail is just due to lack of activation because they don’t contain mineral co-factors. And so that was sort of the big breakthrough I figured out when I was trying to solve the equation of why don’t these things work for me and why don’t they work for everybody else? Was that vegetarian and vegan-based enzymes that are created in the lab are called Apoenzymes. You can look this up in a textbook, they’re literally a classification called apo, which means without, and they’re without their co-factor. Any enzyme that’s created inside of an animal body, whether that’s a pig, a cow, a human, they are called a whole, W-H-O-L-E enzyme. And that basically means there’s an envelope package that contains the mineral.

            And so the PhD guy that got the patent on activating enzymes, that was sort of the big breakthrough, was sort of marrying the three classes of enzymes with their various co-factors to turn them on, and kind of put it all in one capsule so that we cover all the bases. Because like I said, I think between our varied diets and our basically millions of different potential equations for what could be wrong with someone’s gut at a various time point, I’m just trying to build things that don’t fail, and that tends to lead to really good success.

Michael Roesslein:

Yeah. That was actually the enzyme co-factors was something that I’d never heard before and I’ve used like a million different kinds of digestive enzymes. And I noticed too, they were kind of hit or miss. If I took a handful of most of them, I would notice some help, but nobody wants to take a handful of pills. And so I went with more expensive is better. So then I would get the Enzymedica ones and they had the most enzymes in it and the most… What’s the measurement for enzymes? Is it CFUs? No. IUs.

Steven Wright:

Well, actually, each one has their own measurement, which is complicated in the readability of the label.

Michael Roesslein:

Oh, of course. Wonderful. Okay. Yeah. That’s great. Great. Thanks, science. But I thought more was better, so I would get the one with the most enzymes and the highest numbers on the thing. And I never knew anything about co-factors or anything else. So the co-factors actually make sure the enzymes turn on, and that they have what they need to go. And that’s how they’re always found. In nature, the enzymes are with the minerals, so that sense. So that’s a little bit of the why, and what’s in it, and how it works.

            This is where I throw in my popcorn testimonial. I can eat popcorn without feeling like hell when I eat these enzymes and that was my test, because popcorn’s my only food. And side note unrelated, I found popcorn at a little grocer in my town here in Italy, and Italians do not eat popcorn. And so I was so excited. Not really, it’s not a common thing, so I grabbed it off the shelf and I was like, “Popcorn.” She immediately started speaking to me in English and asked me which city in America I was from, as soon as I touched the popcorn. But I can eat it without bloating and that was my test. And so I mentioned bloating. Who are the candidates, digestive enzymes as a whole? And a lot of practitioners, if you’re on here, you know which clients of yours are probably the ones that would benefit from digestive enzymes. You’ve probably given them other digestive enzymes or recommended them. But what’s what are the biggest red flags that someone could be either enzyme deficient, or just in need of some boosting of enzymes for digestion?

Steven Wright:

It’s all your standard digestive complaints, as well as autoimmune complaints, or just complex client complaints. So, enzymes are stopping pain, they’re stopping bloating, they can be stopping constipation or diarrhea, or at least improving or supporting. I shouldn’t say that. They definitely don’t treat that. But they work especially well for anybody with food intolerances, leaky gut, and bloating, and then beyond that, for people who have mild stool irregularities, either soft or hard, they tend to regulate that. But there’s a whole class of people, the Hashimoto’s people and the rheumatoid arthritis people that don’t identify as having a gut issue, but all their symptoms go back to a dysregulated immune system, a dysregulated microbiome, probably a leaky gut, and so those individuals tend to be very helped as well, and they’re the ones that get the weird testimonials where they’re like, “Wow, that rash just went away and never comes back,” or, “I used to have this environmental allergy and that’s gone,” or, “My fingers would swell up and those go away.”

            So I think from a practitioner standpoint, at least when I was seeing people as a consultant, I put everybody on enzymes. To me, they’re like vitamin D, they’re like magnesium. They’re, there’s no question, if they’re coming to me, they’re not getting all the nutrients they need from their food and so I want to try to remove that variable for at least the first 60 to 90 days of working with them to see if it helps. And then, we can cycle off of them and try new things. But that’s how I worked and everybody has their own philosophy.

Michael Roesslein:

Makes sense. Yeah. And I’m kind of the same with enzymes, both digestive, systemic, enzymes to me are kind of if somebody’s coming to me for help, this is part of the foundational package that somebody would get. Because if you’re not getting the nutrients out of your food, you’re not going to get better. And you mentioned auto immunity and that the autoimmune folks, like, “I had this rash, or I had this symptom,” or they don’t view themselves as having a digestive issue, what about enzymes, what would be the potential mechanism there of how would taking enzymes with their food result in lessened symptoms for somebody with autoimmune potentially or less inflammation?

Steven Wright:

Well, I’m still not aware of any other research besides Fasano’s research suggesting that leaky gut and gut dysfunction is a precursor to autoimmune condition. So until that theory is invalidated I still take the point of view that if you have autoimmune-related conditions, if you have complex multi-system inflammatory issues like name any one of those random, crazy disorders, the inflammation and the issues start in the gut and they’re perpetuated in the gut. And that’s the big thing, is that they keep happening on a regular basis. And that local inflammation on a daily basis becomes systemic over the month, over the years. And so we want to do whatever we can to stop the inflammation cascade, get them the nutrients they need for their body to heal. As we’re all aware now, 80% of our immune cells are located in the gut. So anything that we can do to soothe and regulate the gut immune connection is going to go systemic and help support, whether it’s a Hashimoto’s like a thyroid autoimmunity, or a brain autoimmune, or a joint autoimmunity.

Michael Roesslein:

Okay. Makes sense. And I’ve also heard the theory that part of the problem with leaky gut and autoimmune is that these undigested proteins are making it through gut lining and not recognized and cause red flags and all of that. And the enzymes can help break those down into pieces that don’t trigger that same thing. I haven’t seen a clinical study that demonstrates that. I’ve just heard a lot of researchers and scientists talk about that’s a proposed, it would make sense.

            So typical symptoms, nutrient deficient, inflammatory conditions, bloating, gas, diarrhea, constipation, all these types of things, not breaking down food properly, not absorbing the food properly. How does dosing work with this one? For me personally, in my experience, I just usually take two with a meal. And then if I’m eating something that if either, if I’m eating more or something different than something I know doesn’t make me feel awesome, I’ll up that a little bit, three, four. But I don’t have inflammatory gut issues. I don’t have IBS. I don’t have Crohn’s. I don’t have IBD. I don’t have these like drastic symptoms with whole categories of food. I’m not someone, if I look at a bowl of lettuce, I get bloated. So in the more acute situations for practitioners with people who have pretty significant digestive issues, what recommendations do you make as far as titrating or dosing goes? And this is not medical advice for anyone. I’m just going to keep saying that.

Steven Wright:

Yeah. Yeah. It’s informational purposes only. So, I mean, let’s start with the safety profile in humans. We know that enzymes have been used in humans for multi-decades. I don’t know four or five decades now. So our longterm safety profile is pretty well established in humans. I always like to go to the edges of the edge cases and just see what’s happening. And so for instance, Dr. Nicholas Gonzalez was a really famous cancer doctor who passed away, he uses systemic enzyme therapy. Systemic enzymes are just enzymes taken without food. Digestive enzymes are taking the same enzymes with food. There are some specialty enzymes that are extra studies and extra cool for systemic reasons, but digestive enzymes can still work systemically if just taken without food.

            So anyways, in the systemic enzyme area, Dr. Nicholas Gonzalez gave people, and his lineage of doctors give people 130 to 160 capsules a day on an empty stomach. And they have some pretty decent testimonials and some pretty good results in their lineage. So we know that the safety profile for enzymes in humans is much greater than the back of the bottle. And it’s usually much greater than what’s even talked about in your standard nutrition or functional medicine courses. They don’t tend to really cover this kind of stuff.

            And so I think one of the missing pieces to this as a practitioner that you can bring in, whether you use our product or anyone else’s enzymes is just know the fact that 34% of the people you see statistically will be on the long tail of a bell curve. So statistics, there’s a bell curve in the middle. There’s two big chunks, that’s your one standard deviation off of the norm. Those people will probably do just fine with two capsules with the meals, just like Michael does. However, 34% of people either need more or less. And because of the safety profile, I really want to encourage people to open up their dosing ranges and encourage their clients to play around. Try four, try six, try eight, if you want with food. I haven’t really heard of any of our customers needing eight.

            We do have some of our customers who take six, and if I’m going to be out at a restaurant and I know I’m going to have a glass of wine, and I might be getting gluten cross-contaminated, or they might put some seed oil or something junky in my food, I’m taking six personally, but I have kind of a weak gut and long history of issues. And so I think that’s the biggest thing is when it comes to enzymes, people are not increasing the dosing enough and they’re not playing around with it. That’s the difference between a great practitioner and a mediocre practitioner, right there, in one statement.

            So play with the dosages. Up the dosages, whether it’s holozymes or other enzymes, because the difference for somebody who needs four enzymes and someone who needs two enzymes is literally the difference between them thinking that you’re an amazing practitioner, or them seeking out the next practitioner in three months and leaving your practice. Because if they can actually break down their food and stop having these digestive complaints, they will stick around. They will get better, things like that. So that would be the big thing around dosing.

            And then with holozymes, I’m a big proponent of taking them systemically. If you have a different systemic enzyme you use, like a specialty enzyme, I know there’s Fibreza and some other ones, [inaudible 00:21:24], that’s great too, if you use dosing practice. But if you don’t want to carry two brands and you want one that also has human research studies on it, HoloZyme does have that. And so taking two to six on an empty stomach, one time per day is another great way to lower inflammation, kind of clean up that blood, those extra proteins you talked about earlier, that could be getting into the body and not being filtered by the liver and kidneys properly. And again, that’s just something where you got to play with the dosage, give it a shot. I take them in higher doses systemically, after a big workout, if I’m run down, if I’m-

PART 1 OF 4 ENDS [00:22:04]

Steven Wright:

Out if I’m run down, if I’m traveling, and I’m worried about getting sick or something, or any sort of pain. When I go hunting, I take more, try to recover faster, things like that.

Michael Roesslein:

All right. I think that’s pretty clear. Enzymes are tons of safety studies for decades. There’s no contraindications with the enzymes either. I know with some enzymes there are, with blood thinners, but you don’t have lumbrokinase or nattokinase in this formula, right?

Steven Wright:

No.

Michael Roesslein:

So there’s no contraindications that you’re aware of with…

Steven Wright:

Not that I’m aware of, but obviously, if you have weird reactions, stop the product right away.

Michael Roesslein:

Yeah.

Steven Wright:

Talk to somebody, email us, support a healthy gut, things like that.

Michael Roesslein:

Okay. Yeah. They got great support. Any of our people that have reached out have been really happy with the level of support. Am I frozen? Are you frozen?

Steven Wright:

It must be me.

Michael Roesslein:

Are you frozen or am I frozen?

Steven Wright:

Check one, two, check, check.

Michael Roesslein:

Okay.

Steven Wright:

Can you hear me?

Michael Roesslein:

Somebody drop in the chat that you can see and hear us, and we’re not frozen would be helpful at some point. But cool. So no contraindications that you’re aware of. We did the dosing. We did the ingredients. We did the who. All right. So with meals, for digestion away from meals, more systemic. And let’s go to the next one. The next one we did was Tributyrin-X, so we can do that. And this is butyrate. We talked in that webinar, pretty much extensively about butyrate and the different forms that can be supplemented in. And it was sodium butyrate is the normal one, I think, that was traditionally what it was. But you had to take a ton of it, and then you’re consuming a lot of sodium with it.

            And this tributyrin molecule, the way that it’s structured, this is kind of new-ish, a new way to deliver butyrate to the large intestine. That’s the short, abbreviated version. So you can probably do a little better than that, but why did you create this one? What is butyrate doing in the large intestine, or I guess systemically? Because I learned a lot of that webinar, that it’s a lot more than just what it does in the large intestine. But what is butyrate? Why the Tributyrin versus sodium butyrate? And what does it do?

Steven Wright:

Yeah, butyrate is a short chain fatty acid. And if you need to hear this 100 more times, I understand, because it took me a really long time to really understand butyrate short chain fatty acids, what’s happening in the gut with them. But I was aware of butyrate short chain fatty acids for six or seven years, and when my health issues flared up three and a half years ago, I didn’t have these tools from healthy gut. I just had my old tools, and the HCL and enzymes I was taking. The other probiotics and probiotics I was taking, still wasn’t getting the job done. And I was still having bloating, inflammation, food reactions. And so I was like, well naturally, I got to get the sodium butyrate stuff on board. And I tried several brands and dosages and I couldn’t figure it out.

            I couldn’t get really the results that were shown in literature. Which the results in the literature are things like less pain in the gut, which that’s my family history. That’s my body history, is visceral hypersensitivity. So I was hoping for less visceral hypersensitivity, less inflammation in the gut. That’s all been shown even with sodium butyrate. Recovery from loose stools and diarrhea, I don’t really have that. And then support with constipation, which is more what I tend to. Increases in leaky gut healing, things like this. But when I took these products, I couldn’t physically feel it and none of my symptoms were really getting better. So that just kind of tells me there’s an opportunity, right? Whenever we see a ton of people saying, “Hey, this should work.” And then when I test it, and I don’t see results on myself, and then I talk to other physicians and health practitioners, and they kind of told me the same thing. “Oh yeah, we used this one for a little while. Then we switched to this one. Then we switched to this one.”

            And I don’t know, it’s transformative for some people, but not for everybody. That’s when I know there’s an opportunity to innovate and make something better for everybody. And so that’s where tributyrin came. Which was again, first asking the question, why is this not working? And it appears to be that one of the reasons why it’s not working is that the sodium butyrate, the cal mag butyrate molecules are immediately taken up at the membrane level of the small intestine at the top of the small intestine. So they don’t need digestion. There’s these things called gradients. I still don’t completely understand them, but it’s basically like a chemistry equation of where the concentration is higher or lower, and then it just gets sucked right across the membrane. That’s how diffusion happens in cell walls. It’s just crazy cool stuff. Maybe one day I’ll have my true biochemical major, but I’m not there yet.

Michael Roesslein:

Science magic.

Steven Wright:

Yeah.

Michael Roesslein:

Where are your fancy animations? I’m just kidding.

Steven Wright:

Totally. Totally.

Michael Roesslein:

One time I looked into having cool animations to go with the webinar we were doing. I looked into having cool animations made, and then I found out how much it costs to do cool animations. And I was, “Oh, all right then, more respect to all those people who do have cool animations.” But yeah, it’s just a way of it diffusing kind of. The cell just sucks it into wherever it isn’t.

Steven Wright:

Right. And so that’s one of the potential reasons why the salt-bonded butyrates don’t seem to get universal results with people. And the tributyrin molecule is a fat backed butyric acid molecule that has to use a little lipase to break apart. And so it naturally coats the small intestine, and hopefully, it’s going to get into the large intestine. It doesn’t need to. There’s nothing that suggests that you have to put butyric acid in the large intestine for it to work systemically or locally. In fact, if you look at the enema studies on sodium butyrate, which again, the majority of your butyric acid in the body is made in the upper large intestine. If you’re using an enema, you’re going to put it in the lower large intestine. Those studies are actually inconclusive. There’s about 50/50 shot that you’re going to get help or hurt on those, especially in ulcerative colitis studies for butyrate enemas. So a lot of people wonder [crosstalk 00:28:58]-

Michael Roesslein:

That’s because the butyrate isn’t made where the enemas go, so it’s probably not super native to there.

Steven Wright:

I think that’s one part of it. I think that’s one part of it. I think the other part is just injecting a bunch of sodium into your colon might be a bad idea. I know there is some salt down there, and it is a salty place, but that-

Michael Roesslein:

That’s a lot of salt though. The sodium butyrate is a lot of salt versus [crosstalk 00:29:27]-

Steven Wright:

Yeah, think about it. You can go make salty liquid water and go kill your plants. You can go put it on your driveway and get rid of weeds and stuff. So sodium is beautiful. Without it, we die, too much of it, we die. So we got to get it in the right solution for our bodies. And I just think that it was the first generation. It’s really easy to work with in the lab and chemistry-wise. It’s not carcinogenic usually, so it’s very easy to give to people without worrying, are they going to be having an issue. But technology’s moved on. It’s like Windows 95 versus Windows whatever we’re on now. I don’t even use Windows, so [crosstalk 00:30:07]-

Michael Roesslein:

Windows 1007. I have no idea.

Steven Wright:

Yeah. And so that’s what tributyrin is. And I think that’s why tributyrin works a lot better. There’s also studies suggesting that in… There was a rat study where they gave IV sodium butyrate and oral tributyrin , and the oral tributyrin improved the plasma levels of butyric acid better than the IV sodium butyrate. So it’s in a mouse and in a rat, but still, that’s a red flag. If you ever see an IV get beat by an oral substance, you know that [crosstalk 00:30:45]-

Michael Roesslein:

An oral substance is much, much more effective.

Steven Wright:

Yeah. Yep. So you know something weird is going on there. And then they’ve done some pork lung tissue studies, where they bathe these inflamed cells in different types of butyric acid. So they butyric acid. They do sodium butyrate. They do tributyrin , and then they up the concentration to see what the anti-inflammatory level is. And sodium butyrate appears to have kind of a U curve where, in the middle dosage ranges, it’s very helpful. But it’s very not helpful in small dosages, and it’s very harmful in high dosages. And tributyrin and butyric acid, which there’s no brands out there that have just straight butyric acid. The only way that that’s found is in your gut. You can’t just get that. It has to be bonded to something.

            But tributyrin and butyric acid are just straight up and to the right, meaning that the higher the concentration, the higher the anti-inflammatory effect. These have not been replicated in humans yet, but so far, all the research is suggesting really good stuff. The other thing that’s cool is tributyrin was given to cancer patients at over 40,000 milligrams a day, and they only experienced mild GI discomfort, mild blood sugar dis-regulation in one type two diabetic. 40,000 units is a whole bottle of Tributyrin-X. Nobody would do that. There’s never been a study above 4.5 grams of [crosstalk 00:32:15]-

Michael Roesslein:

But you said 400,000.

Steven Wright:

42,000.

Michael Roesslein:

[Crosstalk 00:32:22] whole bottle?

Steven Wright:

Yeah.

Michael Roesslein:

42 grams.

Steven Wright:

Yeah, 42 grams.

Michael Roesslein:

Jesus. Okay.

Steven Wright:

So it’s about a 10 X-

Michael Roesslein:

And that didn’t have a toxic effect, and that’s a lot more than you would be taking or using in your practice.

Steven Wright:

Yeah. So again, when it comes to what are we seeing in the toxicity profiles for humans, from a practitioner standpoint, our data on tributyrin is, we at least have some safety data that suggests that it’s not toxic at 10 X the dosage that you would use with somebody on a regular basis. But we don’t have that data with sodium butyrate.

Michael Roesslein:

Okay. Let’s you mentioned dosing a lot, unless there’s more things you want to talk about, butyrate, tributyrate, butyrin, anything else that it-

Steven Wright:

I’ll just say the last component, because people ask a ton of questions about this. If you powder of supplement, you got to think this through, and as a practitioner, I’m going to hold you to a higher standard than the public. When you’re choosing your products, I know there’s lots of things like the back of the label and how much it costs and who the brand is, but you got to really think about the sacrifices that are made for the creation of it. If you take a naturally liquid a product and you powder it, you’re introducing a bunch of carrier substances and caking agents. You can’t do that manufacturing process without it. And so all the powdered tributyrins out there, I do not like them.

            You can ask their companies for their data sheets. Their data sheets, as far as I have seen, all show the usage of omega six seed oils, to basically powder tributyrin . And it also reduces the strength of it. So ours is 99.9% pure tributyrin. Most of the powder stuff I found is 30% standardized tributyrin , and then you have all those 70% of those carrier oils. And so that’s why I’m a big fan of either Pure Encapsulations, which I know is pure as well, except for their coloring and their flavoring, and then ours. And so that’s why Tributyrin-X was built. That’s why it works better. It’s cleaner. It’s more powerful, those types of things.

Michael Roesslein:

Okay. That makes sense. Powderizing a fatty acid is something that requires extra ingredients and a much more complicated process, but why do they put flavorings in something that’s a capsule? The pure encapsulation ones, is it in a gel thing like yours?

Steven Wright:

No. It’s liposomal liquid.

Michael Roesslein:

Oh, okay.

Steven Wright:

Yeah. So it’s really good for kids under two, whereas ours are-

Michael Roesslein:

Can’t take. Yeah. Yours are tiny though. Those are small. I just did my little, I don’t know what that’s called, your thing with all the little things where you put your supplements for the week. I was literally just finishing mine before I came on here, and yours are the smallest things that I take. So they are small, if anybody on here hasn’t seen them. They’re they’re a little tiny, yeah, squishy little gel cap things. Okay, butyrate, tributyrin, why the formula is like it is, why you created it. Who’s the candidates for this one, main candidates? I remember when we talked about this on the webinar, you brought up that… This is an aside or not an only.

            But people with histamine intolerance and mass cell issues, the people with the hyper reactive systems to everything, you guys have been seeing a lot of positive results in those groups. Which is pretty incredible given the fact that they react if they like pick up a bottle of a supplement a lot of the time and don’t even take it. So that’s the most reactive group of folks that are out there. So I know that that was mentioned. I know a lot of practitioners, oftentimes, aren’t really sure what to do when they run into somebody that’s that reactive to things. So that’s one group of people, but who else and what else would be indications for potential usage of tributyrin in a practice?

Steven Wright:

Yeah. You mentioned the first group of people, which is the super reactive, super sensitive histamine or leaky gut, never ending people. The second big group that’s helped right away is loose stool people. And then third group is the sort of complex inflammatory people, who also tend to have lots of reactions either to supplements or to foods or just to life. But in general, they just can’t seem to get their inflammation bathtub lowered, so that they can just be in alignment with their environment. These are oftentimes mold people as well, that type of thing, those complex viral people like the tick borne illness people. So basically, because butyric acid, think about it, one of the things we’re always going to try to correct for as a practitioners, a microbiome imbalance, at some point. You’re going to check them for a parasite. You’re going to check them for a SIBO or a SIFO, or a candida, or whatever you check for, whatever you focus on.

            The microbiome testing out there right now, it’s kind of weak. It’s pretty pathetic, honestly. It’s not very repeatable. You can’t really compare one company to the other company. You have to just keep using one company over and over again and kind of build up a thing. So I don’t know that we can really measure dysbiosis, but we know that that’s happening. And I think that’s why I haven’t focused on dysbiosis all that much, or what’s the right microbiome profile? Instead we want to focus on, I think, how do we create the conditions for the microbes, the right ones, to grow? What kind of food do they need? What kind of environment do they need?

            And so if you have too much oxygen in your large intestine, you cannot grow the good bacteria. You literally can’t grow. Bacteria, they’re hypersensitive to oxygen, and they need a low oxygen environment. That’s why they’re called anaerobic bacteria. It means without oxygen. So if your body has switched due to antibiotics, due to mold injury, due to lifestyle injury, due to whatever, if your body has the colonocytes, if they’ve switched their metabolism away from butyric acid and oxygen to glucose or something else, where they’re not sucking oxygen out of your intestine, there’s no amount of probiotics or prebiotics or killing programs that are going to reset that microbiome environment. You’ve got to get the oxygen out of there. And the only way to really get the oxygen out is to give the body more butyric acid.

            So the colonocytes switch back to metabolizing with butyric acid, and then they start sucking the oxygen out. Then it’s almost like we’re putting a biodome in there, and we’re creating the right environment, like trying to land on the surface of Mars. We got to reset the oxygen area to allow life to flourish, the right life that we want. And so that’s where I think Tributyrin-X is amazing. And it’s one of the reasons why the testimonials are just so profound, I think, because there’s not really any other substances out there that can do this work. We can feed someone all the vegetables we want, but if we don’t have the butyrate supporters or the butyrate producers, they’re still not going to make the butyric acid. And there’s just not a lot of probiotics that you can take that will effectively restore those colonies. And so I think it’s, you start with a supplemental tributyrin. I would support Tributyrin-X, but of course, like I said, Pure Encapsulations makes a good one as well. And then you add back in your probiotics and your prebiotics.

Michael Roesslein:

That’s pretty fascinating, what it’s able to do and kind of flip the metabolic switch in the gut that I think a lot of people, it gets flipped the other way. And then, like you said, you’re in an uphill situation where the things aren’t working on the right fuel. There’s there’s oxygen there, so the downstream effects of flipping that can be pretty traumatic and comprehensive. Dosing-wise, I don’t even think we really talked about this much on the webinar. So for practitioners working with people that they want to give the tributyrin a go, where do you start with the dosing? You said people have taken 1 million milligrams of it, so I’m guessing there’s not a too high, but is there a, you titrate from low to high?

Steven Wright:

Yeah.

Michael Roesslein:

How do you get started? Where do you find the sweet spot? What do you recommend?

Steven Wright:

So again, if you take nothing away from this, just take away the fact that the dosage of the products you give people matter as much or more than the brand you give people. And everybody’s going to have a unique dosage, even in your patient population. Even if they’re all SIBO people, or all mold people, they’ll have different dosages. And so if you have someone who’s very sensitive, they’re a mold person, they’re a histamine-related person, they’re just generally identify as a sensitive individual, we recommend you start with one pill every three days and slowly build up. On the ninth day, you’d start taking it one pill every day, and then you’d slowly build from there to as many pills as you need per day.

            Now, how would you know when you’ve hit that right amount? Well, the cool thing about tributyrin is that it is a motility regulator. And so the one side effect of it is, it will slow down your digestive track too much. And it’s actually paradoxical, because if you get a slow GI track in response to one or two capsules, that actually is a decent sign, at least at one capsule or one capsule every few days. It’s a decent sign you’re actually super deficient in it, is what I’m learning. You should be able to handle one of these per day, if not two of these per day. If you get extreme constipation reaction to that, it’s typically a sign of deficiency. Again, it’s a U curve, but we don’t want that, of course. No one wants constipation, and we don’t want to exacerbate anybody’s problems. And so we go slow.

            Most people will end up around the two to three per day, which is why there’s 90 capsulesF in the bottle. Some people who are loose stool or diarrhea-oriented individuals, they will need more. And so they will be in the four to six per day. As you mentioned, the studies in humans have gone up to 42 grams a day. The whole bottle only contains 45 grams, so I haven’t heard of anyone taking more than 16 in a day. And that person was 55 years old, had never had a formed bowel movement in their entire life, had tried every single pharmaceutical and every single nutraceutical. And we had had a long conversation back and forth. And so she’s on four, four times a day, and she’s having her first formed bowel movements. And she’s the happiest woman in the world.

Michael Roesslein:

Wow. That’s fun.

Steven Wright:

Yeah. So there’s really cool stuff that can happen [crosstalk 00:43:45]. And for those people who get… For instance, I wanted to find where I would get stopped up. And so somewhere around four to five is when I get pretty constipated. And six, I kept pushing it because I’m a big dummy like that, and I want to always find the edge.f